{"id":"W7140149731","doi":"","title":"Limiting Autoimmune Neuroinflammation using Novel T Cell Suppressants & Investigating Overlapping Lysosomal Reductase Function in Macrophages and Osteoclasts","year":2019,"lang":"en","type":"dissertation","venue":"Open MIND","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"Experimental autoimmune encephalomyelitis; T cell; Autoimmunity; Antigen; Antigen presentation; Cathepsin; Transient receptor potential channel; Immune system; Proteolysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335239,0.000240781,0.000206076,0.0002415592,0.0001061264,0.0002332239,0.0001749165,0.00019035,0.000904767],"category_scores_gemma":[0.00006067269,0.00007671386,0.0002575218,0.0001263928,0.0001333858,0.0001759357,0.0001319496,0.0003617592,0.0001646548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725929,"about_ca_system_score_gemma":0.0002180301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002372436,"about_ca_topic_score_gemma":0.0006679511,"domain_scores_codex":[0.9999572,0.000005845603,0.000003435974,0.000009624928,0.000011951,0.00001192487],"domain_scores_gemma":[0.9999739,0.000002655564,0.000007928202,0.000002448956,0.000005195006,0.000007748314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002972535,0.0001000627,0.0001657833,0.0002573446,0.00001115871,0.00009473439,0.00002768703,0.0002115106,0.9857389,0.0003857572,0.0001889047,0.01252076],"study_design_scores_gemma":[0.0001354022,0.002987046,0.001490339,0.00003231008,0.0000585132,0.0003662872,0.0000389044,0.0006509004,0.9789489,0.0001271283,0.01515381,0.00001051455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677942,0.0207191,0.00484464,0.0003267945,0.00008581181,0.0002111302,0.0004827956,0.0001063804,0.005429107],"genre_scores_gemma":[0.972853,0.01607127,0.006525918,0.0002334104,0.0000449999,0.0001117506,0.0003700774,0.00001604628,0.003773491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000904767,"threshold_uncertainty_score":0.003026724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03324456738562895,"score_gpt":0.283839976416183,"score_spread":0.2505954090305541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}