{"id":"W7144643965","doi":"","title":"Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold","year":2022,"lang":"en","type":"article","venue":"Institutional Repositories DataBase (IRDB)","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Okinawa Institute of Science and Technology Graduate University; University of Toronto","keywords":"Diphtheria toxin; Toxin; Conserved sequence; Wolbachia; Model organism; Host (biology); Diphtheria; Translation (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188944,0.0002314798,0.000294324,0.0002938008,0.0002141165,0.000365837,0.0001690607,0.0002498452,0.0008769362],"category_scores_gemma":[0.0003243106,0.0001336639,0.0001928912,0.0004138046,0.0001305885,0.0002945878,0.0003072585,0.0004256147,0.0003358142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003498426,"about_ca_system_score_gemma":0.0002367163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144863,"about_ca_topic_score_gemma":0.001148087,"domain_scores_codex":[0.9999317,0.000009775896,0.000006389459,0.00001925797,0.00001800325,0.0000148702],"domain_scores_gemma":[0.9998538,0.00002618031,0.00004175195,0.00001930556,0.00001787415,0.00004108219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005963919,0.00005336607,0.01169717,0.0001206224,0.00002619334,0.0008670177,0.0002842958,0.001187471,0.975898,0.0008524649,0.0003119277,0.008105182],"study_design_scores_gemma":[0.0001312364,0.0008284939,0.4352598,0.00008504943,0.0001941294,0.00494724,0.00122656,0.02282121,0.5059671,0.001626834,0.02683298,0.00007930299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966414,0.0006542313,0.001333828,0.00005574237,0.000005981107,0.000006865867,0.0003065494,0.00004893391,0.0009465224],"genre_scores_gemma":[0.995887,0.0002687374,0.001903377,0.00004004208,0.000003379519,0.000004239825,0.001349893,0.00001361651,0.0005298781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144863,"threshold_uncertainty_score":0.002933621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774547620997865,"score_gpt":0.2436314726287913,"score_spread":0.2258859964188126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}