{"id":"W7147334668","doi":"10.1093/immadv/ltaf038","title":"Chimeric CD3ζ chains containing CD28 signalling motifs enhance antigen-specific IL-2 production and expansion of human TCR-engineered T cells <i>in vitro</i>","year":2025,"lang":"en","type":"article","venue":"Immunotherapy Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"CD28; T-cell receptor; Cytotoxic T cell; Chimeric antigen receptor; Antigen; Effector; Streptamer; Signal transduction; Jurkat cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770797,0.0004793767,0.0001870404,0.0001344137,0.00006459781,0.0002957317,0.0001166039,0.0002446775,0.001135181],"category_scores_gemma":[0.0001005238,0.0001086101,0.0002170842,0.00009243127,0.000117617,0.0001110307,0.0001610765,0.0005401447,0.0005036122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001741062,"about_ca_system_score_gemma":0.00009407357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003105196,"about_ca_topic_score_gemma":0.0003178659,"domain_scores_codex":[0.9998152,0.00003475878,0.0000174106,0.00003399435,0.00004343145,0.00005531348],"domain_scores_gemma":[0.9999098,0.00003071237,0.00001514008,0.00001080795,0.0000110015,0.00002255045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008971818,0.00003225939,0.00005932826,0.00001024728,0.000001785943,0.00002266413,0.000007528427,0.0001002217,0.9991917,0.00001931163,0.00002138053,0.0004438199],"study_design_scores_gemma":[0.00002128533,0.000301417,0.0007371927,0.000002843099,0.000008858367,0.00008821615,0.000007130815,0.001292861,0.9967729,0.0000121151,0.0007533642,0.000001762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994427,0.0005274024,0.003257958,0.00003915181,0.00002651002,0.0000449378,0.0002227067,0.00007409592,0.001380243],"genre_scores_gemma":[0.9952711,0.0002181943,0.0024811,0.00003667324,0.00001238024,0.00002841604,0.0004266959,0.00002016431,0.001505253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135181,"threshold_uncertainty_score":0.003797531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0151106043424515,"score_gpt":0.3019183049404314,"score_spread":0.2868077005979799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}