{"id":"W7154961155","doi":"10.1093/jncimonographs/lgaf044","title":"Cancer epigenetics: unraveling etiology and mechanisms to advance prevention","year":2025,"lang":"en","type":"article","venue":"JNCI Monographs","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Epigenome; Epigenetics; Cancer; Cancer prevention; International agency; Carcinogenesis; Epigenesis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674038,0.0001252935,0.0001218124,0.0001196324,0.00008963318,0.00001923875,0.00009488207,0.0001411228,0.000008545761],"category_scores_gemma":[0.00004777362,0.00013086,0.00005759225,0.0001843639,0.00003383848,0.000002417967,0.00009517566,0.00005612149,0.000002130425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008985458,"about_ca_system_score_gemma":0.0000507527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003115862,"about_ca_topic_score_gemma":0.0001969842,"domain_scores_codex":[0.9991444,0.00005068842,0.0001913443,0.0003558777,0.00006173423,0.0001959531],"domain_scores_gemma":[0.9995559,0.00001146486,0.00005309725,0.0002264775,0.00008432131,0.00006867325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005668227,0.00003214483,0.01086501,0.00002442836,0.00005977856,4.448468e-7,0.0000504388,0.001038206,0.9285939,0.002096655,0.0002149806,0.05696734],"study_design_scores_gemma":[0.0005494111,0.0004326096,0.02246266,0.00006235551,0.00005173262,6.54647e-7,0.0000968954,0.0002576706,0.8886669,0.03313265,0.05398055,0.000305953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6643201,0.00530262,0.3290377,0.0002667645,0.0002902329,0.0002422272,0.00001159602,0.00001239012,0.0005164423],"genre_scores_gemma":[0.9827586,0.003629158,0.01218223,0.0004093736,0.00006989687,0.000103709,0.0000423517,0.00001389869,0.0007907735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3184386,"threshold_uncertainty_score":0.5336315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008252921853801476,"score_gpt":0.3060791339637692,"score_spread":0.2978262121099677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}