{"id":"W7154961155","doi":"10.1093/jncimonographs/lgaf044","title":"Cancer epigenetics: unraveling etiology and mechanisms to advance prevention","year":2025,"lang":"en","type":"article","venue":"JNCI Monographs","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Epigenome; Epigenetics; Cancer; Cancer prevention; International agency; Carcinogenesis; Epigenesis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00138704,0.0005286892,0.00100167,0.001454136,0.000538883,0.001641959,0.0006402706,0.001126078,0.006593625],"category_scores_gemma":[0.001908522,0.0002200155,0.0005434842,0.001127705,0.001166378,0.002197628,0.001400749,0.002506046,0.001743933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001293262,"about_ca_system_score_gemma":0.003135396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002546219,"about_ca_topic_score_gemma":0.005601472,"domain_scores_codex":[0.9996125,0.0001213503,0.00003118098,0.00007210141,0.0001230918,0.00003977567],"domain_scores_gemma":[0.999294,0.0003003002,0.0000639756,0.00004798195,0.0002038497,0.00008983859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001078428,0.00006673546,0.00422277,0.005758812,0.0002109975,0.0003486358,0.0005301768,0.000821139,0.01318864,0.05123703,0.0950734,0.8284338],"study_design_scores_gemma":[0.00001021085,0.00008666583,0.005181708,0.002736504,0.0001477206,0.0007195701,0.000366307,0.0004243339,0.00280674,0.03030603,0.9571751,0.00003917023],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002000702,0.9331663,0.008799895,0.04084874,0.004351464,0.00003733973,0.0004161954,0.0001650683,0.01021419],"genre_scores_gemma":[0.01235898,0.9687749,0.005091876,0.004783677,0.003100103,0.00003912792,0.0003244687,0.00003361679,0.005493242],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006593625,"threshold_uncertainty_score":0.02205783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008252921853801476,"score_gpt":0.3060791339637692,"score_spread":0.2978262121099677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}