{"id":"W7160078579","doi":"10.5281/zenodo.20022109","title":"PACTAMYCIN: A COMPREHENSIVE REVIEW OF ITS BIOLOGICAL ACTIVITY, BIOSYNTHESIS, AND SYNTHETIC STRATEGIES IN THE FIGHT AGAINST ANTIBIOTIC RESISTANCE","year":2025,"lang":"en","type":"article","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Privy Council Office","funders":"","keywords":"Natural product; Antibiotic resistance; Synthetic biology; Antimycobacterial; Metabolic engineering; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000448494,0.0001242749,0.0002347795,0.00010083,0.0004813816,0.0001930578,0.0005502274,0.00006356226,0.001351251],"category_scores_gemma":[0.0008567483,0.00009224545,0.00005423523,0.0004287545,0.0001864967,0.0001117379,0.0002920904,0.0001980929,0.0001090598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004996149,"about_ca_system_score_gemma":0.000007938719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003842692,"about_ca_topic_score_gemma":5.298373e-7,"domain_scores_codex":[0.9988077,0.0002724233,0.0002397126,0.0002945077,0.0001944308,0.0001912789],"domain_scores_gemma":[0.9990059,0.0002301707,0.0001142681,0.0004113792,0.0001996173,0.00003871151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002305284,0.001066188,0.00003840227,0.02018056,0.0002487608,0.0000517843,0.001057778,0.000007603974,0.6237335,0.02264877,0.08902743,0.2417088],"study_design_scores_gemma":[0.0002200005,0.0000294444,0.002051606,0.004161201,0.00003539615,0.00002785364,0.00133058,0.00003175631,0.02422943,0.000129972,0.9675999,0.0001528323],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2795414,0.02563528,0.0001038842,0.007347884,0.00005449254,0.0009152722,0.0003745537,0.0003226033,0.6857046],"genre_scores_gemma":[0.9785978,0.02067212,0.00001765049,0.0002435635,0.00001687452,1.257133e-7,0.00009284035,0.0001184044,0.0002406492],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8785725,"threshold_uncertainty_score":0.9995617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04028421956907736,"score_gpt":0.2714996174149965,"score_spread":0.2312153978459192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}