{"id":"W7160087120","doi":"10.5281/zenodo.20022110","title":"PACTAMYCIN: A COMPREHENSIVE REVIEW OF ITS BIOLOGICAL ACTIVITY, BIOSYNTHESIS, AND SYNTHETIC STRATEGIES IN THE FIGHT AGAINST ANTIBIOTIC RESISTANCE","year":2025,"lang":"en","type":"article","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Privy Council Office","funders":"","keywords":"Natural product; Antibiotic resistance; Synthetic biology; Antimycobacterial; Metabolic engineering; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003109438,0.0007235259,0.0008717588,0.001748492,0.0002757199,0.0008217331,0.000486608,0.0005708386,0.002955078],"category_scores_gemma":[0.0003411794,0.0002628456,0.0004100017,0.00212963,0.0002788273,0.001263304,0.0004489365,0.00107392,0.00132492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004213477,"about_ca_system_score_gemma":0.0008019453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006604503,"about_ca_topic_score_gemma":0.001021256,"domain_scores_codex":[0.9998524,0.00002259488,0.00002401967,0.00002950322,0.00005179523,0.00001948306],"domain_scores_gemma":[0.9998748,0.00004243352,0.0000290352,0.000005416474,0.00003103333,0.00001728867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001769437,0.0001460642,0.00037678,0.02953964,0.00009683693,0.0003765749,0.0001611829,0.001166304,0.03011329,0.007339154,0.02244044,0.9080669],"study_design_scores_gemma":[0.00001042797,0.0001999168,0.0008879222,0.001318779,0.00009107535,0.0008728072,0.00004342478,0.0002135739,0.004519541,0.00115536,0.9906628,0.00002431553],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001067954,0.9956748,0.0006247671,0.0002284018,0.0001693412,0.00001100781,0.00005860256,0.00002032623,0.002144695],"genre_scores_gemma":[0.003691264,0.9939965,0.0006430438,0.0001647058,0.0001888478,0.00001260604,0.0001094488,0.00000508609,0.001188489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002955078,"threshold_uncertainty_score":0.009885728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04028421956907736,"score_gpt":0.2714996174149965,"score_spread":0.2312153978459192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}