{"id":"W7161840565","doi":"10.82308/55","title":"Design, synthesis and evaluation of selective estrogen receptor modulator/histone deacetylase inhibitor merged bifunctional ligands","year":2014,"lang":"en","type":"dissertation","venue":"","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Antiestrogen; Tamoxifen; Selective estrogen receptor modulator; Estrogen receptor; Bifunctional; Pharmacophore; Cytotoxicity","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370128,0.0003388846,0.0002889936,0.0002614031,0.0001363268,0.0002306459,0.0003678581,0.0002997129,0.001550848],"category_scores_gemma":[0.0001042439,0.0001252393,0.0002240446,0.0002699281,0.0001131493,0.0002390337,0.0002760668,0.0003394086,0.0004378337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721669,"about_ca_system_score_gemma":0.0001670332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006121828,"about_ca_topic_score_gemma":0.001284974,"domain_scores_codex":[0.9999152,0.00001005624,0.000005976288,0.00001953538,0.0000217765,0.00002741552],"domain_scores_gemma":[0.9999628,0.000002358915,0.000007707134,0.000002450083,0.000008861286,0.00001581278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003243969,0.0001957419,0.0002879119,0.0002582278,0.00005207902,0.0001771346,0.00004653487,0.002379832,0.9690455,0.001096284,0.0004857806,0.02565059],"study_design_scores_gemma":[0.0001929111,0.003682368,0.001876507,0.00003384457,0.0001284456,0.000424089,0.00007282461,0.006517993,0.9556909,0.0001618882,0.03117576,0.00004249398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9510334,0.006858438,0.03112435,0.000259062,0.00007644761,0.0004083767,0.001127563,0.0003245458,0.008787834],"genre_scores_gemma":[0.9740622,0.002867727,0.01742738,0.000167221,0.00001496462,0.0001931258,0.0008466709,0.00002202996,0.00439862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550848,"threshold_uncertainty_score":0.005188107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009843719326008365,"score_gpt":0.269359778364353,"score_spread":0.2595160590383446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}