{"id":"W7161849495","doi":"10.82308/35437","title":"Uncovering novel ShcA signaling networks and their impacts on breast cancer growth and therapeutic resistance","year":2023,"lang":"en","type":"dissertation","venue":"","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Breast cancer; Acquired resistance; Signal transducing adaptor protein; Druggability; Signal transduction; Tyrosine kinase; Cancer; Disease; Receptor tyrosine kinase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482531,0.0002283767,0.0001771602,0.0002427086,0.0002304731,0.0005192935,0.0001534607,0.0001889612,0.00177071],"category_scores_gemma":[0.00009841732,0.000133727,0.0002850613,0.0002006673,0.0001431426,0.000295019,0.0002245159,0.0004808121,0.0003384634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004198468,"about_ca_system_score_gemma":0.000340596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006684869,"about_ca_topic_score_gemma":0.001035952,"domain_scores_codex":[0.9999409,0.000005432662,0.000002871052,0.00001201453,0.00002263739,0.00001619291],"domain_scores_gemma":[0.9999665,0.000005667286,0.00001029925,0.000002151551,0.000007095825,0.000008249722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002728513,0.00009163803,0.002949451,0.000264013,0.00003156758,0.0002582487,0.00008518119,0.0009974305,0.9669524,0.001708541,0.0008492693,0.02553937],"study_design_scores_gemma":[0.00004575675,0.0004719329,0.04865232,0.00008148548,0.00012637,0.0006777417,0.0004189922,0.007129091,0.9125369,0.001628768,0.02821323,0.00001732581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661258,0.01637977,0.004959149,0.0009507379,0.00005509114,0.00006475791,0.0007228925,0.0001092948,0.0106325],"genre_scores_gemma":[0.9632851,0.02026413,0.003954234,0.0002296446,0.00002529327,0.00006533258,0.0007595619,0.00002183669,0.01139478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177071,"threshold_uncertainty_score":0.005923569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149103205247166,"score_gpt":0.263554681214589,"score_spread":0.2520636491621174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}