{"id":"W7161935883","doi":"10.82308/19260","title":"Mechanisms of action of antidepressants and their combination for major depressive disorder treatment: a theoretical and clinical approach","year":2014,"lang":"en","type":"dissertation","venue":"","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Antidepressant; Major depressive disorder; Depression (economics); Mood; Mood disorders; Action (physics); Adverse effect; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002620879,0.001050517,0.00119103,0.008698044,0.0006227212,0.002848328,0.001447658,0.001587212,0.004562493],"category_scores_gemma":[0.002823748,0.0004072877,0.001379859,0.003839477,0.001213611,0.003106061,0.001074283,0.00124808,0.001022802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002014405,"about_ca_system_score_gemma":0.004205457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008601291,"about_ca_topic_score_gemma":0.002495881,"domain_scores_codex":[0.9989507,0.0004444226,0.0001659081,0.00008956942,0.0003077248,0.00004168552],"domain_scores_gemma":[0.9984065,0.0009496784,0.0002510616,0.00003257893,0.0003217389,0.00003852802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003622947,0.0003241292,0.002066023,0.1676944,0.000654613,0.001419805,0.001008922,0.001149803,0.003111865,0.06479983,0.01568372,0.7417246],"study_design_scores_gemma":[0.0002843326,0.002391987,0.009965668,0.1986965,0.003203962,0.01009028,0.003701016,0.00193152,0.002848361,0.06281856,0.7039369,0.0001309613],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001501894,0.9823141,0.001637073,0.007267186,0.0004028777,0.0001516162,0.0001137794,0.00001376483,0.006597567],"genre_scores_gemma":[0.01491703,0.9777975,0.003665364,0.001873334,0.0005216945,0.0002785541,0.00007734977,0.000003034923,0.0008659942],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008698044,"threshold_uncertainty_score":0.01526308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341019710137982,"score_gpt":0.3420791852271765,"score_spread":0.3186689881257966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}