{"id":"W7161937561","doi":"10.82308/15665","title":"Nonsense suppressor therapy of cystinosis","year":2018,"lang":"en","type":"dissertation","venue":"","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cystine; Mutation; Cystinosis; Nonsense mutation; Renal tubule","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001267991,0.0001372462,0.0004183721,0.0001461855,0.0000217947,0.00000270858,0.00009423116,0.0004006108,0.006107905],"category_scores_gemma":[0.0003323055,0.00008889033,0.0001476244,0.0001405643,0.0001428057,0.000009140528,0.000009771399,0.0002450569,0.000181217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009689007,"about_ca_system_score_gemma":0.0002975592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001195822,"about_ca_topic_score_gemma":0.00002913351,"domain_scores_codex":[0.9989113,0.00004616623,0.0002388892,0.0002185701,0.00035895,0.0002261549],"domain_scores_gemma":[0.9989882,0.0001382947,0.0000854079,0.0002833363,0.0003149009,0.0001898836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006361917,0.0003731146,0.0001204391,0.0005903609,0.0002365278,0.0000512163,0.0003113961,2.485787e-9,0.8462926,0.00007263436,0.0827235,0.06286626],"study_design_scores_gemma":[0.002973806,0.005431142,0.05068557,0.0005918076,0.00007303102,0.0000213705,0.0003639848,0.00003028637,0.8550192,0.0005885696,0.08395174,0.0002695259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9404534,0.000705498,0.000008951081,0.0002699069,0.0003419252,0.0003948308,0.00003966842,0.00003041368,0.05775541],"genre_scores_gemma":[0.8765278,0.004599323,0.00269949,0.0007819844,0.0009667824,0.00006632193,0.004013931,0.00006794929,0.1102764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06392561,"threshold_uncertainty_score":0.9948006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03696993566705216,"score_gpt":0.370310514377896,"score_spread":0.3333405787108438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}