{"id":"W7161971040","doi":"10.82308/43897","title":"Computer-aided design and synthesis of papain-like protease and 3-chymotrypsin-like protease inhibitors involved in the replication of SARS-CoV-2","year":2023,"lang":"en","type":"dissertation","venue":"","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Protease; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); DNA replication","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007549771,0.0008938471,0.001182715,0.0004858143,0.0004446007,0.001079402,0.0008360871,0.0006937363,0.00564882],"category_scores_gemma":[0.000610088,0.0005802806,0.00113162,0.0006614188,0.0002397397,0.0004041344,0.0003491768,0.0009502826,0.001292984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007742455,"about_ca_system_score_gemma":0.001696998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002048719,"about_ca_topic_score_gemma":0.004018152,"domain_scores_codex":[0.9996204,0.00006507631,0.00002681356,0.00007844942,0.0001431697,0.00006607301],"domain_scores_gemma":[0.999878,0.00004420156,0.00002457933,0.00001033393,0.00002898624,0.0000139201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001689307,0.00104985,0.001645454,0.003682419,0.0003003977,0.0009938452,0.0003141887,0.3294579,0.5354523,0.01849602,0.006234759,0.1006835],"study_design_scores_gemma":[0.001018438,0.003086205,0.001012161,0.0001842928,0.0002601804,0.0003458984,0.0001599146,0.3746777,0.5367596,0.001933892,0.08044238,0.0001193776],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6943175,0.02139769,0.224701,0.001449013,0.000517334,0.00185124,0.007049917,0.003070152,0.04564616],"genre_scores_gemma":[0.6662776,0.0124585,0.2988829,0.0002910247,0.00004117947,0.001532022,0.005915557,0.0003323898,0.01426889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00564882,"threshold_uncertainty_score":0.01889718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03968862073410254,"score_gpt":0.2955375188273665,"score_spread":0.2558488980932639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}