{"id":"W7161992983","doi":"10.82308/27573","title":"Investigation of the co-operativity of mutations in the mitogen-activated protein kinase (MAPK) pathway in cutaneous melanomas","year":2022,"lang":"en","type":"dissertation","venue":"","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Kinase; MAPK/ERK pathway; Protein kinase A; Mutation; Neuroblastoma RAS viral oncogene homolog; Mutant","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002796575,0.0001573864,0.0001703202,0.0009605538,0.0002582931,0.0003086816,0.0001165527,0.0002884967,0.001647664],"category_scores_gemma":[0.0006880882,0.0001298831,0.0002306593,0.0005014314,0.0001581627,0.0002194439,0.0001684279,0.00024285,0.0002815513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372839,"about_ca_system_score_gemma":0.0001350396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005538759,"about_ca_topic_score_gemma":0.0005471806,"domain_scores_codex":[0.9997709,0.00004925746,0.00002296102,0.0000582573,0.00005397197,0.00004459536],"domain_scores_gemma":[0.9994878,0.0001414319,0.0001419628,0.00002818066,0.00008396718,0.0001167246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001657123,0.0002531167,0.8669687,0.0001200628,0.00008410675,0.005789547,0.0003835961,0.00010322,0.1077743,0.0001010623,0.0001430321,0.01662215],"study_design_scores_gemma":[0.00001427604,0.0007710847,0.9734564,0.00001062762,0.00007126069,0.01490278,0.0004696063,0.0002396389,0.008614702,0.00006268483,0.001380196,0.000006598262],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998588,0.0006047994,0.0001269793,0.00001665739,0.000004988993,0.000007856546,0.00005559282,0.000003644012,0.0005913606],"genre_scores_gemma":[0.9991965,0.0002068293,0.000135282,0.000009205268,0.000005742727,0.000005776508,0.00006923607,0.000001909197,0.0003696535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647664,"threshold_uncertainty_score":0.00551194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433138842117311,"score_gpt":0.2475315848297287,"score_spread":0.2332001964085555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}