{"id":"W7162002379","doi":"10.82308/13181","title":"I. Hybrid androgen receptor antagonist – Histone deacetylase inhibitors and II. development of an oxy-Cope / Michael cascade reaction","year":2022,"lang":"en","type":"dissertation","venue":"","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Histone deacetylase; Androgen receptor; Prostate cancer; Vorinostat; Histone deacetylase inhibitor; Drug discovery; Epigenetics; Histone; Prostate","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002642507,0.0006553761,0.0002522312,0.0003351021,0.0001845169,0.0002427827,0.0003943207,0.0004235755,0.003222613],"category_scores_gemma":[0.000137414,0.0003272647,0.0004895976,0.0002288333,0.0003420163,0.0006554589,0.0005914681,0.0006856747,0.001503445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003656897,"about_ca_system_score_gemma":0.0003805774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004071322,"about_ca_topic_score_gemma":0.0005353724,"domain_scores_codex":[0.9998528,0.00001618296,0.000009863279,0.00003273228,0.00004262198,0.00004574338],"domain_scores_gemma":[0.999964,0.000004934632,0.00001291687,0.0000052446,0.000005075005,0.000007861658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003261909,0.0002765677,0.0003972871,0.0009020092,0.00005881934,0.0005648204,0.0001468529,0.001981877,0.9157697,0.02251583,0.003381962,0.05367798],"study_design_scores_gemma":[0.0001538538,0.003546303,0.001529579,0.00006208944,0.00004841695,0.00125319,0.00004237792,0.003593074,0.9204711,0.001849222,0.06738581,0.00006492474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.59978,0.0347143,0.2216743,0.001916083,0.001683195,0.002159835,0.001944778,0.00219964,0.133928],"genre_scores_gemma":[0.8891962,0.02048585,0.05834834,0.0009632177,0.0002347814,0.0009992101,0.001143322,0.0001101141,0.02851892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003222613,"threshold_uncertainty_score":0.01078069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167817726286778,"score_gpt":0.3215634255992635,"score_spread":0.3047816529705857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}