{"id":"W7162003114","doi":"10.82308/22731","title":"Design, synthesis, and biological evaluation of novel antiestrogens","year":2013,"lang":"en","type":"dissertation","venue":"","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Estrogen receptor; Virtual screening; Estrogen; Breast cancer; Cancer; Drug discovery; Estrogen receptor beta; SUMO protein","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003213848,0.0003401894,0.0004099632,0.0003401251,0.0001944539,0.0002868533,0.0003561885,0.0002483601,0.001597811],"category_scores_gemma":[0.0001945306,0.0001778024,0.0003176993,0.0003352718,0.0001334462,0.0002677076,0.0002167136,0.0003768241,0.0004044932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814592,"about_ca_system_score_gemma":0.0003132572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004952059,"about_ca_topic_score_gemma":0.001580096,"domain_scores_codex":[0.9998634,0.00002588786,0.00001376918,0.00002499384,0.00004814542,0.00002374494],"domain_scores_gemma":[0.9999374,0.000009015843,0.00001184143,0.000006376998,0.00002098038,0.00001443166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000642613,0.0005980399,0.0004800315,0.0009893356,0.00009355257,0.0003794986,0.00008667784,0.009406708,0.9315073,0.002466356,0.0009038586,0.05244609],"study_design_scores_gemma":[0.0004256387,0.006545196,0.001918401,0.00006915459,0.0000985873,0.0003426574,0.0000608,0.005514642,0.9283936,0.0003963285,0.05620284,0.00003203379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.911661,0.03206625,0.0334553,0.0005776768,0.0001988212,0.0009663477,0.003262379,0.0003103442,0.01750193],"genre_scores_gemma":[0.9408735,0.02323353,0.02598895,0.00032776,0.00004253003,0.0002644203,0.001996152,0.00003746599,0.00723573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597811,"threshold_uncertainty_score":0.005345225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03553581673099947,"score_gpt":0.2931288646634307,"score_spread":0.2575930479324313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}