{"id":"W7162029207","doi":"10.82308/29803","title":"Investigating the early role of oxidative stress in Alzheimer’s disease: Insights from a transgenic model of the amyloid pathology and fluorescence imaging methods","year":2022,"lang":"en","type":"dissertation","venue":"","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Oxidative stress; Neuroinflammation; Genetically modified mouse; Disease; Transgene; Amyloid (mycology); Biomarker; Dementia; Gene expression; Inflammation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002722101,0.0006964699,0.0003033064,0.0005010651,0.0002709869,0.0004499065,0.0003725146,0.0007338015,0.000922167],"category_scores_gemma":[0.00006633569,0.0002933549,0.0005003983,0.0002001107,0.0003747272,0.0005465572,0.0002077222,0.001322888,0.0003705102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004768908,"about_ca_system_score_gemma":0.0003859357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008625716,"about_ca_topic_score_gemma":0.001802735,"domain_scores_codex":[0.9999154,0.00000603275,0.000004722343,0.00002421341,0.00003146799,0.00001816343],"domain_scores_gemma":[0.9999325,0.000009485293,0.00002205944,0.000006872568,0.00001529211,0.00001384179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006222636,0.0001134799,0.0001549902,0.0001358969,0.000006190971,0.0001245137,0.00007158775,0.00007956816,0.9919415,0.0008880844,0.0003308991,0.006091169],"study_design_scores_gemma":[0.00005692867,0.002272377,0.0114558,0.0001909333,0.0001473001,0.002010284,0.0001532507,0.001646154,0.9406312,0.002948915,0.03843025,0.00005654817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8044554,0.05929997,0.1049649,0.00493347,0.0006511097,0.0004912458,0.001271086,0.001366509,0.02256639],"genre_scores_gemma":[0.7612004,0.1107529,0.08376588,0.001248077,0.0002604008,0.0006671368,0.001412427,0.0001644538,0.04052828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000922167,"threshold_uncertainty_score":0.003460169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03283875234561055,"score_gpt":0.3460113821811268,"score_spread":0.3131726298355162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}