{"id":"W7162083492","doi":"10.82308/28035","title":"Elucidating the Transcriptional Regulatory Roles of STAT3 and FOXA1 Transcription Factors in Genetically Engineered Mouse Models of Human Breast Cancer","year":2024,"lang":"en","type":"dissertation","venue":"","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Breast cancer; STAT3; Metastasis; Transcription factor; FOXA1; Gene knockdown; Estrogen receptor; Cancer; Metastatic breast cancer; Cancer cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206224,0.000216531,0.0004070019,0.0002814514,0.0000366223,0.00001387896,0.00006512729,0.0001668353,0.0002972881],"category_scores_gemma":[0.000007473111,0.0001526329,0.0001736176,0.0001342981,0.00005212411,0.00008245398,0.000004143716,0.000354381,2.503109e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000060086,"about_ca_system_score_gemma":0.0001538303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007713023,"about_ca_topic_score_gemma":0.002421623,"domain_scores_codex":[0.9986596,0.00002662668,0.000613443,0.0002507148,0.000313119,0.0001364635],"domain_scores_gemma":[0.9994533,0.00004164075,0.0001148025,0.0001565718,0.0001811557,0.00005250459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557924,0.0001004091,0.0001859986,0.0008227352,0.0001548864,9.192979e-7,0.006164562,0.001109491,0.9865358,0.003867252,0.00004528212,0.0008568148],"study_design_scores_gemma":[0.001426035,0.0003455588,0.117884,0.003193808,0.0009327041,0.00001887491,0.01274528,0.016978,0.8448565,0.001141968,0.00006825347,0.0004089767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966832,0.001305412,0.0003077115,0.00009527312,0.0001475786,0.0003451044,0.0004433997,0.00002715022,0.0006451186],"genre_scores_gemma":[0.9975289,0.0002206573,0.00009957847,0.00001436013,0.00006095076,0.00003695558,0.0006718773,0.00004426051,0.00132247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1416793,"threshold_uncertainty_score":0.6224189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02417187908319879,"score_gpt":0.2865476850605388,"score_spread":0.26237580597734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}