{"id":"W7162100784","doi":"10.82308/13719","title":"Design, synthesis, and biological evaluation of selective estrogen receptor modulator/histone deacetylase inhibitor hybrid drug molecules","year":2020,"lang":"en","type":"dissertation","venue":"","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Raloxifene; Pharmacophore; Selective estrogen receptor modulator; Tamoxifen; Breast cancer; Estrogen receptor; Histone deacetylase; Oestrogen receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714531,0.0002568837,0.0002530787,0.0002244001,0.0001331395,0.0002980877,0.0002616976,0.000270105,0.001763267],"category_scores_gemma":[0.0001141221,0.0001676129,0.0002784368,0.0001743785,0.00009505465,0.0002414963,0.0001835737,0.0003608538,0.0004754322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843379,"about_ca_system_score_gemma":0.0001552569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001950007,"about_ca_topic_score_gemma":0.0004452458,"domain_scores_codex":[0.9999254,0.00001046953,0.000005614887,0.0000176282,0.0000223561,0.00001850787],"domain_scores_gemma":[0.9999691,0.000004489754,0.000008086862,0.000002362478,0.000007778573,0.00000816398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002616521,0.0003005457,0.0002499193,0.0007558899,0.00006239926,0.0002442741,0.00008773311,0.003018525,0.9608584,0.003383805,0.001060787,0.02971605],"study_design_scores_gemma":[0.0001437555,0.003697147,0.0008643947,0.00004766158,0.0000813716,0.0002754446,0.00005031134,0.003554672,0.947188,0.0003109532,0.04375632,0.00003007223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9372228,0.01429929,0.02255463,0.0005797807,0.0002670204,0.0007387944,0.001467282,0.0003036804,0.02256665],"genre_scores_gemma":[0.9530116,0.01108667,0.02445148,0.0002814042,0.0000355225,0.0004860849,0.0009414002,0.00003433577,0.009671536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763267,"threshold_uncertainty_score":0.005898654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415538944682962,"score_gpt":0.2724447824414936,"score_spread":0.2582893929946639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}