{"id":"W7162122644","doi":"10.82308/47540","title":"Barriers to personalized medicine in pediatrics: The implementation of a novel pharmacogenomic test for pediatric neuroblastoma","year":2015,"lang":"en","type":"dissertation","venue":"","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacogenomics; Test (biology); Personalized medicine; Pediatric cancer; Palliative care; Deliberation; Genetic testing; Stakeholder","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0516185,0.000350391,0.0005316804,0.0006891329,0.00425049,0.003471496,0.001635671,0.001903131,0.002358626],"category_scores_gemma":[0.1091265,0.0005602361,0.0008441157,0.0006101333,0.003070656,0.003516244,0.006482472,0.003058617,0.0002392795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006661074,"about_ca_system_score_gemma":0.02429938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002827726,"about_ca_topic_score_gemma":0.004975827,"domain_scores_codex":[0.9281481,0.05894954,0.002495699,0.001535726,0.005027378,0.003843659],"domain_scores_gemma":[0.8712195,0.09629261,0.01564936,0.00275203,0.00593694,0.008149681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"observational","study_design_scores_codex":[0.001360276,0.004622006,0.201263,0.003113038,0.0001429903,0.004454191,0.5798731,0.001238098,0.003151401,0.003939747,0.003913326,0.1929288],"study_design_scores_gemma":[0.0003692268,0.01542305,0.1632935,0.004108156,0.0003651854,0.003707061,0.7470501,0.003888708,0.007251285,0.004162987,0.05012621,0.0002546004],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871142,0.0004357555,0.002192738,0.006690802,0.00005608209,0.0009161281,0.00004937252,0.0000279837,0.002516862],"genre_scores_gemma":[0.9816097,0.0006825352,0.01366074,0.001888587,0.00002635534,0.001671195,0.00003329569,0.00001264722,0.0004149443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0516185,"threshold_uncertainty_score":0.272988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08543492254270567,"score_gpt":0.4747735906642536,"score_spread":0.3893386681215479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}