{"id":"W7163904772","doi":"10.2196/84625","title":"Point-of-Care Nucleic Acid Tests (POC NATs) for HIV Testing and Viral Load Monitoring: A longitudinal, prospective study with randomized-controlled trial, qualitative, and systems engineering components to assess feasibility, acceptability, and test performance of POC NAT in the United States (Preprint)","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Viral load; Human immunodeficiency virus (HIV); Prospective cohort study; Test (biology); Nucleic acid; Test strategy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.009792239,0.0002625736,0.001283817,0.0006371764,0.0002005878,0.0001778555,0.0001914772,0.00007370923,7.851628e-7],"category_scores_gemma":[0.02411353,0.000169436,0.00006043549,0.001216553,0.0003002054,0.0001942308,0.0002687337,0.000543299,1.811998e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284518,"about_ca_system_score_gemma":0.0002052365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002430912,"about_ca_topic_score_gemma":0.00002394171,"domain_scores_codex":[0.9962595,0.001152631,0.0008754975,0.0005846595,0.0007486074,0.0003791589],"domain_scores_gemma":[0.9821573,0.01533086,0.0002428167,0.0003904891,0.00179886,0.00007964981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.330906,0.001063542,0.642594,0.004093971,0.0001126542,0.000005176889,0.00794597,0.00003513118,0.01304018,0.00001960884,0.000001856679,0.0001818979],"study_design_scores_gemma":[0.6711867,0.0123474,0.261915,0.007353333,0.00005447088,0.00001672542,0.02458389,0.0110273,0.01123696,0.00006267902,0.000007647948,0.0002079548],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6211535,0.00002740729,0.00002020716,0.00003620523,0.000006834066,0.3786882,0.000007041502,0.00002965837,0.00003099563],"genre_scores_gemma":[0.6059143,5.907034e-7,0.0004709146,0.000003451174,0.00001612328,0.393574,8.526769e-7,0.00001445269,0.000005372586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3806791,"threshold_uncertainty_score":0.9841068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2239729681947861,"score_gpt":0.5142883387288929,"score_spread":0.2903153705341068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}