{"id":"W7164450267","doi":"","title":"DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutationcarriers","year":2014,"lang":"en","type":"article","venue":"Florence Research (University of Florence)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; Cancer Center, University of Kansas; National Institutes of Health; Ministero dello Sviluppo Economico; Fox Chase Cancer Center; Uppsala Universitet; Associazione Italiana per la Ricerca sul Cancro; Deutsche Krebshilfe; National Cancer Institute; Landspítali Háskólasjúkrahús; Hungarian Scientific Research Fund; Lunds Universitet; Sahlgrenska Universitetssjukhuset; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Breast Cancer Foundation; European Commission; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; Beckman Research Institute, City of Hope; Cancer Research UK; University of Chicago; Instituto de Salud Carlos III; Hope Funds for Cancer Research; Royal Marsden NHS Foundation Trust; McGill University; European Social Fund; Canadian Breast Cancer Research Alliance; State Education Development Agency Republic of Latvia; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, San Francisco; Ministero della Salute; National Health and Medical Research Council; Kansas Bioscience Authority","keywords":"DNA glycosylase; Base excision repair; DNA repair; Single-nucleotide polymorphism; Mutation; MUTYH; Synthetic lethality; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006855403,0.0004953903,0.0005322189,0.001109101,0.0003798389,0.0004530062,0.0003069622,0.0006517342,0.001835326],"category_scores_gemma":[0.00232323,0.0002984665,0.0005733611,0.0009389879,0.0003858448,0.0002125762,0.0003483048,0.0004664044,0.0001814572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505133,"about_ca_system_score_gemma":0.0001646049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003310858,"about_ca_topic_score_gemma":0.00295227,"domain_scores_codex":[0.9995839,0.00009583592,0.00003553976,0.0001734845,0.00005503672,0.00005626778],"domain_scores_gemma":[0.9988784,0.0004247366,0.0003567704,0.0001156132,0.00006394527,0.0001605428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007193974,0.00005458554,0.9835497,0.00002120365,0.0002600001,0.0006973619,0.0002295811,0.00009380898,0.01185788,0.00003887979,0.00005577703,0.002421795],"study_design_scores_gemma":[0.00001823435,0.0001211049,0.9979665,0.000004264278,0.0001355549,0.0008107867,0.00007197781,0.0001270887,0.0005595842,0.00005441104,0.0001258943,0.000004649079],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995815,0.0001904964,0.00006302519,0.00001310283,0.000001864483,0.000002622953,0.00007287744,0.000002700046,0.00007169512],"genre_scores_gemma":[0.9993367,0.00008911623,0.0001524142,0.00001881496,0.000006698426,0.000005749994,0.0001858896,0.000004192451,0.0002005454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003310858,"threshold_uncertainty_score":0.006583154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609398294444212,"score_gpt":0.2775719312459924,"score_spread":0.2514779483015502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}