{"id":"W7165450767","doi":"10.82308/55718","title":"Investigating the relative biological effectiveness of clinically relevant photon energies and the intrinsic radiosensitivity of human cancer cell lines towards biologically informed radiotherapy treatments","year":2025,"lang":"en","type":"dissertation","venue":"Open MIND","topic":"Radiation Therapy and Dosimetry","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund; McGill University Health Centre","keywords":"Relative biological effectiveness; Ionizing radiation; Radiosensitivity; Radiation therapy; HeLa; Linear energy transfer; Radiobiology; Cancer; Brachytherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008124138,0.0003154507,0.0004415938,0.0005161768,0.0002359846,0.001010428,0.0003348013,0.0005807896,0.001494724],"category_scores_gemma":[0.00144465,0.0002324332,0.0003989911,0.000552427,0.000326236,0.0004075067,0.0003893488,0.0009085156,0.0004647712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003824415,"about_ca_system_score_gemma":0.0003421623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006543351,"about_ca_topic_score_gemma":0.0007904141,"domain_scores_codex":[0.9993002,0.0001402219,0.00006238312,0.0001290118,0.0003107337,0.0000573644],"domain_scores_gemma":[0.9990977,0.0003788436,0.0001741834,0.00007872294,0.0002401556,0.00003057158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000189276,0.00008610337,0.005251553,0.0005710623,0.00005866943,0.00008383826,0.0002543349,0.002060608,0.9774553,0.000423362,0.0002368666,0.013329],"study_design_scores_gemma":[0.000008620586,0.001551814,0.02558164,0.000096461,0.0001112871,0.0004439754,0.0003488436,0.001941568,0.9622746,0.0003026691,0.007306418,0.00003225992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662665,0.01358825,0.01391528,0.0003101186,0.00005898258,0.0001294811,0.001112954,0.0001036178,0.004514825],"genre_scores_gemma":[0.9734358,0.0113165,0.008841995,0.0002174411,0.00002315903,0.0002237669,0.001744741,0.00005667526,0.004139992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494724,"threshold_uncertainty_score":0.005000412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04878857528913486,"score_gpt":0.3860658515874864,"score_spread":0.3372772762983515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}