{"id":"W73658525","doi":"10.1007/978-1-61779-148-2_17","title":"Protease Specificity Profiling by Tandem Mass Spectrometry Using Proteome-Derived Peptide Libraries","year":2011,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Protease; Proteome; Peptide; Chemistry; Tandem mass spectrometry; Cleavage (geology); Peptide sequence; Scissile bond; Bottom-up proteomics; Biochemistry; Mass spectrometry; Protein mass spectrometry; Biology; Enzyme; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007200241,0.0007278912,0.0007750855,0.001505475,0.0003317704,0.0008052764,0.0004895273,0.0003879416,0.0007101464],"category_scores_gemma":[0.0007459839,0.0003122596,0.0003964546,0.001255655,0.0002858303,0.000543205,0.0004079459,0.0007466018,0.001000804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003147562,"about_ca_system_score_gemma":0.0003141707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001550394,"about_ca_topic_score_gemma":0.0003593438,"domain_scores_codex":[0.9992884,0.000104361,0.00005191774,0.000175911,0.0003202007,0.00005922834],"domain_scores_gemma":[0.9995533,0.0001117299,0.0001030899,0.00005661641,0.0001161672,0.00005917047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001097341,0.00003267899,0.0003744631,0.00005545857,0.00001763256,0.00003644114,0.000009441809,0.0002100113,0.9917791,0.0001497889,0.000154361,0.007070867],"study_design_scores_gemma":[0.00002177159,0.0001522909,0.002469807,0.000005519429,0.00003511554,0.000332098,0.00001083322,0.004579616,0.9891425,0.0002972983,0.002935258,0.00001781291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5457636,0.003809052,0.4338011,0.0003170608,0.0001206584,0.0005805542,0.007779808,0.003533308,0.004294718],"genre_scores_gemma":[0.5161848,0.004983369,0.4597311,0.0004638004,0.0001398655,0.0008511693,0.01288197,0.0003330577,0.004430796],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001505475,"threshold_uncertainty_score":0.003807902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04566065880587458,"score_gpt":0.3614397661727897,"score_spread":0.3157791073669152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}