{"id":"W74426933","doi":"10.1182/blood.v95.3.894.003k15_894_902","title":"Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation*","year":2000,"lang":"en","type":"article","venue":"Blood","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"MARCKS; Phosphorylation; Protein kinase C; Biology; Pleckstrin homology domain; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000252735,0.0005835162,0.0004133823,0.0002211771,0.0001469944,0.0002571025,0.0001377262,0.0003255634,0.001614752],"category_scores_gemma":[0.0001928237,0.0001704876,0.0003506995,0.0001545373,0.0002531134,0.0002371364,0.0001871443,0.0008221431,0.0006974001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971463,"about_ca_system_score_gemma":0.0001661246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002523221,"about_ca_topic_score_gemma":0.0003135743,"domain_scores_codex":[0.9997935,0.00003643416,0.00003616352,0.00002790961,0.00004638739,0.00005968906],"domain_scores_gemma":[0.9997897,0.00005317656,0.00006017453,0.0000314296,0.00001926177,0.00004631468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001530251,0.0000363605,0.00005209525,0.00003943284,0.000003499797,0.00005230368,0.000005613953,0.00001222445,0.9989597,0.00003126993,0.00002111179,0.0006334117],"study_design_scores_gemma":[0.00002498302,0.0003164467,0.002227186,0.000003502996,0.000009941843,0.0002057605,0.000004086327,0.0003064741,0.9958124,0.00001281416,0.001074348,0.000002126434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866784,0.004267084,0.005783135,0.0002849056,0.0001325441,0.0001282047,0.0004086525,0.0002196502,0.002097374],"genre_scores_gemma":[0.9841426,0.003173579,0.00712782,0.0001360308,0.00008715194,0.0001426067,0.001070234,0.00004445359,0.004075554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001614752,"threshold_uncertainty_score":0.00540185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008919457842009702,"score_gpt":0.2299009571910334,"score_spread":0.2209814993490237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}