{"id":"W74426933","doi":"10.1182/blood.v95.3.894.003k15_894_902","title":"Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation*","year":2000,"lang":"en","type":"article","venue":"Blood","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"MARCKS; Phosphorylation; Protein kinase C; Biology; Pleckstrin homology domain; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004540168,0.0004681857,0.0004491519,0.00009380388,0.0002573547,0.00007801684,0.000176104,0.0005314434,0.0007496442],"category_scores_gemma":[0.0001405135,0.0005077414,0.0001348753,0.0003583294,0.00008599489,0.00006530095,0.00007073543,0.00027981,0.0000103672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000499475,"about_ca_system_score_gemma":0.0001077723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003444845,"about_ca_topic_score_gemma":0.00002568305,"domain_scores_codex":[0.9973064,0.0001836277,0.0007476325,0.0008369337,0.0004653847,0.0004600101],"domain_scores_gemma":[0.9986351,0.00007016819,0.0004826382,0.0004152707,0.0002292965,0.0001675865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006594356,0.0002109068,0.006891774,0.00005940585,0.0001696545,0.000002518213,0.001063359,0.0006029307,0.9827371,0.000006471306,0.0001803337,0.007416117],"study_design_scores_gemma":[0.004513501,0.0006435971,0.00417625,0.0001385611,0.0001457595,0.00001705095,0.0003222302,0.005682018,0.9829884,0.0001281519,0.0006846675,0.0005598681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994499,0.0009545522,0.002684303,0.00007291997,0.00009361786,0.00118266,0.00009316475,0.00006730964,0.0003524949],"genre_scores_gemma":[0.9950685,0.0006066267,0.002241081,0.0001520144,0.0001183838,0.00007946123,0.001357105,0.00008541995,0.0002913883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006856249,"threshold_uncertainty_score":0.9997374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008919457842009702,"score_gpt":0.2299009571910334,"score_spread":0.2209814993490237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}