{"id":"W753158220","doi":"10.1007/s10620-015-3797-3","title":"Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease","year":2015,"lang":"en","type":"article","venue":"Digestive Diseases and Sciences","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Trimethylamine N-oxide; Inflammatory bowel disease; Biomarker; Ulcerative colitis; Population; Microbiome; Dysbiosis; Internal medicine; Crohn's disease; Choline; Gut flora; Trimethylamine; Medicine; Immunology; Disease; Gastroenterology; Chemistry; Biology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003204322,0.00007318791,0.00006433755,0.00002952122,0.0001563119,0.00003233046,0.0001416585,0.00002441878,6.818335e-7],"category_scores_gemma":[0.0003649823,0.00004742701,0.00005152579,0.00007356689,0.0004619709,0.000008342759,0.00004705027,0.00001453569,4.99921e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004728085,"about_ca_system_score_gemma":0.0002707478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001818399,"about_ca_topic_score_gemma":0.000001710284,"domain_scores_codex":[0.999375,0.00002073156,0.0001615018,0.0002179619,0.00009709143,0.0001276872],"domain_scores_gemma":[0.9994552,0.00004950316,0.0001027495,0.0001268286,0.0001300858,0.0001356623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002964527,0.0001270588,0.5671076,0.00006777178,0.00002980823,3.717383e-7,0.0001066105,0.0001190983,0.4285039,0.001144619,0.00124121,0.00125558],"study_design_scores_gemma":[0.0003437488,0.00008821832,0.9924428,0.000008824181,0.00003508897,6.920641e-7,0.0003352067,0.0009935232,0.003497221,0.000148724,0.002031287,0.00007460582],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991412,0.005425829,0.002192793,0.0003568933,0.00008808168,0.0002766451,0.0002201954,0.000003795698,0.00002377193],"genre_scores_gemma":[0.9994132,0.0001459248,0.0001069581,0.0001017245,0.00004074716,0.00003181904,0.00003441398,0.000003984994,0.0001212459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4253353,"threshold_uncertainty_score":0.1934017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03597467802157869,"score_gpt":0.3165353411024058,"score_spread":0.2805606630808271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}