{"id":"W778823491","doi":"10.1021/acs.jnatprod.5b00211","title":"Tyrosyl-DNA Phosphodiesterase I Inhibitors from the Australian Plant <i>Macropteranthes leichhardtii</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Queensland Government; Australian Research Council; Griffith University","keywords":"Phenylpropanoid; Bark (sound); Stereochemistry; Phosphodiesterase; Glucoside; Chemistry; Pharmacognosy; DNA; Biological activity; IC50; Enzyme; Biochemistry; Biology; In vitro; Biosynthesis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005315658,0.0002782659,0.0001464397,0.0002534179,0.0001193936,0.0001032163,0.0001048977,0.0001000742,0.0008088127],"category_scores_gemma":[0.00006858036,0.00008833459,0.0001314926,0.0001554965,0.00009744101,0.00009883093,0.0001108026,0.0003411288,0.0001417168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001639277,"about_ca_system_score_gemma":0.0001754591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019851,"about_ca_topic_score_gemma":0.003562937,"domain_scores_codex":[0.9999748,0.000002567294,0.000002502779,0.000006154161,0.00000830059,0.000005605015],"domain_scores_gemma":[0.9999621,0.00000720248,0.000009654228,0.000002860422,0.000006994516,0.00001119807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003809081,0.000008172517,0.0001510187,0.00005745509,0.000003831997,0.00003613681,0.00001261862,0.00004450413,0.9962187,0.00002460407,0.00003051676,0.003374319],"study_design_scores_gemma":[0.00003151638,0.0005986693,0.02241735,0.00002364077,0.00004349082,0.0003409656,0.0000395959,0.0002156278,0.9692708,0.00007274151,0.006938483,0.000007234478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846452,0.005082415,0.003214285,0.0001548122,0.00001611699,0.00008370157,0.0009185611,0.00008463129,0.005800435],"genre_scores_gemma":[0.9863911,0.004106918,0.004352889,0.0001124999,0.00001439074,0.0000552157,0.001852925,0.00002110218,0.003093104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019851,"threshold_uncertainty_score":0.002705693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025495584357939,"score_gpt":0.2530417259347664,"score_spread":0.2275461415768274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}