{"id":"W778823491","doi":"10.1021/acs.jnatprod.5b00211","title":"Tyrosyl-DNA Phosphodiesterase I Inhibitors from the Australian Plant <i>Macropteranthes leichhardtii</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Queensland Government; Australian Research Council; Griffith University","keywords":"Phenylpropanoid; Bark (sound); Stereochemistry; Phosphodiesterase; Glucoside; Chemistry; Pharmacognosy; DNA; Biological activity; IC50; Enzyme; Biochemistry; Biology; In vitro; Biosynthesis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003637811,0.0001597983,0.0001799083,0.00002186926,0.00006406513,0.00006534888,0.0003078837,0.00007883376,0.000004994858],"category_scores_gemma":[0.0001272052,0.0000955337,0.0001053391,0.00007965286,0.00006070774,0.00001319295,0.00006782949,0.0002526932,0.000005435783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002871517,"about_ca_system_score_gemma":0.0001666594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004034566,"about_ca_topic_score_gemma":0.0000316712,"domain_scores_codex":[0.9989736,0.00006237794,0.0003012615,0.0001931491,0.0002678186,0.0002017716],"domain_scores_gemma":[0.9990294,0.00001540448,0.0002686387,0.0002673953,0.0003155568,0.0001036276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005711718,0.00004455792,0.0001768664,0.000005155832,0.0001278955,0.0000260223,0.0003200711,0.0000131423,0.9315053,0.00001935019,0.06245452,0.00473595],"study_design_scores_gemma":[0.0006306444,0.0002401791,0.0001622617,0.00002941255,0.00003687386,0.0001072842,0.0001724195,0.000002282439,0.6847467,0.000138171,0.3136237,0.0001100679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802223,0.01031764,0.00001207201,0.006041298,0.003173331,0.0001212185,0.00005556551,0.000004638126,0.00005186599],"genre_scores_gemma":[0.9945532,0.000391355,0.0004505952,0.001191893,0.002716009,0.000001426117,0.00003482729,0.00001770339,0.0006430043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2511692,"threshold_uncertainty_score":0.3895751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025495584357939,"score_gpt":0.2530417259347664,"score_spread":0.2275461415768274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}