{"id":"W782389661","doi":"10.1007/s11095-015-1741-z","title":"Effect of siRNA pre-Exposure on Subsequent Response to siRNA Therapy","year":2015,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Cure Brain Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Georgetown University","keywords":"Gene silencing; Small interfering RNA; RNA interference; In vivo; Messenger RNA; Viability assay; Cancer cell; In vitro; Cancer research; Cell; Biology; Cancer; Chemistry; Cell biology; Molecular biology; Cell culture; Transfection; RNA; Biochemistry; Gene; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00067415,0.0004509374,0.0007262332,0.0002672348,0.0002737927,0.0006517305,0.0003574057,0.0006168963,0.005646704],"category_scores_gemma":[0.000994719,0.0002657087,0.0004693833,0.0003323982,0.0004013735,0.0003564143,0.0002976308,0.000906653,0.00106665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003810349,"about_ca_system_score_gemma":0.0005768506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001224783,"about_ca_topic_score_gemma":0.001661825,"domain_scores_codex":[0.9993804,0.0001363467,0.00008911937,0.0001162271,0.00008861552,0.0001893313],"domain_scores_gemma":[0.9990699,0.0005728987,0.00006835034,0.00007784058,0.0001091128,0.0001020089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003855606,0.000426847,0.000253602,0.00009141958,0.00002144183,0.00006446061,0.00007782831,0.0001170347,0.9912683,0.00008259764,0.0001952285,0.003545721],"study_design_scores_gemma":[0.00005085021,0.001287874,0.003349989,0.000004615889,0.00003068826,0.00004056433,0.00003122786,0.0003535136,0.9938251,0.00002217489,0.0009928346,0.00001069166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896585,0.003001746,0.001951586,0.0001871505,0.0003509601,0.000158558,0.0005805218,0.0001567975,0.003954087],"genre_scores_gemma":[0.9881323,0.001185258,0.002486886,0.0001586324,0.0000847648,0.0002028689,0.000813935,0.00007787348,0.006857453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005646704,"threshold_uncertainty_score":0.01889008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1628531169623683,"score_gpt":0.4969929895813249,"score_spread":0.3341398726189566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}