{"id":"W782389661","doi":"10.1007/s11095-015-1741-z","title":"Effect of siRNA pre-Exposure on Subsequent Response to siRNA Therapy","year":2015,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Cure Brain Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Georgetown University","keywords":"Gene silencing; Small interfering RNA; RNA interference; In vivo; Messenger RNA; Viability assay; Cancer cell; In vitro; Cancer research; Cell; Biology; Cancer; Chemistry; Cell biology; Molecular biology; Cell culture; Transfection; RNA; Biochemistry; Gene; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004651974,0.0001518281,0.000179688,0.0001341308,0.00005114968,0.00002715551,0.0004301115,0.0001293308,0.00005962248],"category_scores_gemma":[0.00165835,0.0001154901,0.00009430179,0.0002297903,0.0001228964,0.000003843546,0.0002052016,0.0003284476,0.0001892669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004800093,"about_ca_system_score_gemma":0.0001845023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001956158,"about_ca_topic_score_gemma":0.000002433282,"domain_scores_codex":[0.9966897,0.00152687,0.0002043701,0.0003892139,0.0007017948,0.0004879999],"domain_scores_gemma":[0.9983159,0.0003495757,0.00002304721,0.0004496886,0.0003849875,0.0004768495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04220139,0.0001465219,0.001247713,0.000018682,0.00004957184,0.00001647755,0.0001055827,0.00006727545,0.9288236,0.00002215779,0.005909599,0.02139146],"study_design_scores_gemma":[0.001391182,0.01417097,0.0007921305,0.00002311298,0.000004606121,0.000004154561,0.0000194383,0.00006522793,0.9183369,0.00002588235,0.06505576,0.0001106215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957066,0.001021625,0.00004985241,0.0009354307,0.0001186776,0.0005212828,0.00001244317,0.000009041144,0.001625115],"genre_scores_gemma":[0.9979678,0.0002618266,0.0000269721,0.0003961143,0.0001863498,0.00007233142,0.00001015069,0.00002214588,0.001056356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05914616,"threshold_uncertainty_score":0.470955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1628531169623683,"score_gpt":0.4969929895813249,"score_spread":0.3341398726189566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}