{"id":"W787984392","doi":"","title":"The role of Sphingosine Kinase 1 in N-Methyl-D-Aspartate-induced excitotoxicity of mouse retinal neurons","year":2015,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Excitotoxicity; Chemistry; Sphingosine; Retinal; Sphingosine kinase; Pharmacology; Glutamate receptor; Neuroscience; Cell biology; Sphingosine-1-phosphate; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258954,0.0005054587,0.0002237575,0.0006421785,0.0003483106,0.0004570366,0.0003108798,0.000473505,0.0007103132],"category_scores_gemma":[0.0001561062,0.0002852671,0.0003635012,0.0002210603,0.0003603732,0.0005195286,0.0002356576,0.0009016645,0.0002493937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007712495,"about_ca_system_score_gemma":0.0004803083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405077,"about_ca_topic_score_gemma":0.002152794,"domain_scores_codex":[0.9998497,0.00002041611,0.00001885072,0.00003117909,0.00003736906,0.00004244941],"domain_scores_gemma":[0.9998457,0.00001689039,0.00005782348,0.00001775735,0.00002104434,0.00004068785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013787,0.00001268503,0.0002275053,0.00002761214,0.000004984642,0.00009461185,0.00001864474,0.00005983678,0.9984556,0.0002770828,0.00001470087,0.000605285],"study_design_scores_gemma":[0.00001520713,0.0001002313,0.003073889,0.000007185658,0.00001991043,0.0001478814,0.00005208168,0.0004216053,0.995494,0.0001428729,0.0005212897,0.000003838294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913185,0.003847725,0.002538453,0.0003336758,0.00003524912,0.00001796956,0.0004612633,0.00006086368,0.001386444],"genre_scores_gemma":[0.9927489,0.001704426,0.001672316,0.00005328878,0.000006710451,0.00002728885,0.0002406746,0.00001365145,0.003532765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405077,"threshold_uncertainty_score":0.005595863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610188726567434,"score_gpt":0.3214472211226567,"score_spread":0.2853453338569824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}