{"id":"W788622636","doi":"10.1371/journal.pone.0130495","title":"Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Cancer Research Society; Leukemia and Lymphoma Society; University of California, San Diego; Agilent Technologies","keywords":"Biology; Myeloid; Haematopoiesis; Progenitor cell; Cancer research; Leukemia; Myeloid leukemia; Lymphoid leukemia; Stem cell; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001959402,0.0003384817,0.0002349597,0.0002358476,0.0001966447,0.0004414776,0.0003191643,0.000339509,0.001228103],"category_scores_gemma":[0.0001459029,0.0002055495,0.000247092,0.000169074,0.0004120833,0.0002305034,0.0002801584,0.0009525978,0.0004721205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985525,"about_ca_system_score_gemma":0.0002958307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004706871,"about_ca_topic_score_gemma":0.0006568519,"domain_scores_codex":[0.9997531,0.00004226475,0.00003635327,0.00005118617,0.00005673795,0.00006036608],"domain_scores_gemma":[0.9998103,0.00005952748,0.00005289991,0.00003722403,0.000006869913,0.00003318784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003531335,0.00004050086,0.0001052157,0.00001207806,0.000002000037,0.0000340991,0.00001113124,0.00005954075,0.998902,0.0002115556,0.0000127326,0.0005737313],"study_design_scores_gemma":[0.00001091587,0.0001736971,0.0009489136,0.000002915347,0.000006312284,0.0001625208,0.00001199988,0.0005468764,0.996662,0.0000291117,0.001442756,0.000001928298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936354,0.0009048943,0.003666075,0.0000753442,0.00002733214,0.00004139355,0.0003152594,0.000110498,0.001223659],"genre_scores_gemma":[0.9915441,0.0007517125,0.003488732,0.00003394044,0.000008988406,0.00004542858,0.000593699,0.00003394584,0.003499504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228103,"threshold_uncertainty_score":0.004108369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04299927170128614,"score_gpt":0.256130817045588,"score_spread":0.2131315453443018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}