{"id":"W797819430","doi":"","title":"Characterization of Erythromycin Esterases: A Genomic Enzymology Approach to Macrolide Resistance","year":2010,"lang":"en","type":"dissertation","venue":"MacSphere (McMaster University)","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University","keywords":"Erythromycin; Computational biology; Resistance (ecology); Biology; Genetics; Antibiotics; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007543193,0.0002987036,0.0003370295,0.0001534859,0.00006946612,0.00002460351,0.0005673802,0.0007089244,0.001640707],"category_scores_gemma":[0.00002721499,0.0003389157,0.0001660024,0.0002738246,0.00007939173,0.000006244396,0.000191883,0.0003361599,0.00002016259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003554044,"about_ca_system_score_gemma":0.0001668506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003598409,"about_ca_topic_score_gemma":0.0004773837,"domain_scores_codex":[0.9984522,0.00009546996,0.000238493,0.0006845222,0.0001870082,0.0003422888],"domain_scores_gemma":[0.9990289,0.000006797668,0.0001881558,0.000428464,0.0001798472,0.0001677994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000909081,0.0001075412,0.00006878631,0.0002541071,0.00009503193,0.00001264848,0.0001367126,0.000001893127,0.9890947,0.0001410438,0.0003272145,0.008851185],"study_design_scores_gemma":[0.0004800059,0.0001106733,0.0008843498,0.00005366627,0.0000523405,0.000005407226,0.0002143534,0.000002816787,0.6782441,0.00001069492,0.3196238,0.0003178379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8280319,0.0001334085,0.001286042,0.0000388949,0.0001663407,0.0005220811,0.0001382871,0.00001486466,0.1696682],"genre_scores_gemma":[0.2598967,0.0001071959,0.001946508,0.0001473363,0.0001785866,0.00001030649,0.005117996,0.00007997663,0.7325154],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5681351,"threshold_uncertainty_score":0.9999063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007742276926430749,"score_gpt":0.2148905073328975,"score_spread":0.2071482304064667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}