{"id":"W800577","doi":"10.1042/bst20130164","title":"Programmable DNA cleavage <i>in vitro</i> by Cas9","year":2013,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Centre for Addiction and Mental Health","keywords":"Trans-activating crRNA; CRISPR; Cas9; Endonuclease; Genome editing; DNA; Biology; Computational biology; RNA; Cell biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003388449,0.0007812059,0.0008492788,0.001342605,0.0001666881,0.0006299444,0.0008077121,0.0006658739,0.001296949],"category_scores_gemma":[0.0002935928,0.0003858861,0.0003752615,0.001334704,0.00040153,0.000776246,0.0004375554,0.001207546,0.001986538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000714828,"about_ca_system_score_gemma":0.0004477047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009774901,"about_ca_topic_score_gemma":0.001321691,"domain_scores_codex":[0.9998389,0.00001973521,0.0000186595,0.00003534492,0.0000675148,0.00001980943],"domain_scores_gemma":[0.9998926,0.00003578176,0.00002226035,0.000005388264,0.00003066788,0.00001330298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007442826,0.00006137272,0.0001466685,0.007414071,0.00007894481,0.0002176788,0.00004438567,0.0008818675,0.02321328,0.0056538,0.01971566,0.9424978],"study_design_scores_gemma":[0.00001449811,0.00007060915,0.0005677031,0.0005594034,0.00004083638,0.0008283678,0.00002056153,0.0003419653,0.0137224,0.001105412,0.9827056,0.00002253157],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009759953,0.9920083,0.001818356,0.0002736138,0.000268277,0.00001408414,0.00003950876,0.00005825923,0.004543596],"genre_scores_gemma":[0.004507499,0.9907033,0.001581013,0.0001893402,0.00009948444,0.00001760062,0.0000930399,0.000008509602,0.002800264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001342605,"threshold_uncertainty_score":0.005186439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242399919993983,"score_gpt":0.3086618710121977,"score_spread":0.2962378718122579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}