{"id":"W802300164","doi":"10.1371/journal.pone.0132061","title":"Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; Children's Hospital Foundation; National Institutes of Health; Michael Smith Health Research BC; BC Children's Hospital","keywords":"Biology; Gene expression; Gene; Young adult; Transcriptome; Context (archaeology); Innate immune system; Immunology; Immune system; Monocyte; Gene expression profiling; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305347,0.0001478991,0.0002813583,0.0001106885,0.00008722986,0.00001850852,0.0001227944,0.000261765,0.0001524671],"category_scores_gemma":[0.00008835793,0.0001264055,0.00002249959,0.00007162565,0.00009410362,0.0001565153,0.00008280731,0.0002254217,0.0001288671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002773576,"about_ca_system_score_gemma":0.00001824955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241657,"about_ca_topic_score_gemma":0.0001214328,"domain_scores_codex":[0.9989535,0.0002108027,0.0003142711,0.0002570844,0.0000517934,0.0002125494],"domain_scores_gemma":[0.9995489,0.00007622502,0.000106047,0.0001875879,0.0000559942,0.00002531402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007414286,0.0004276702,0.04060925,0.00002029621,0.0001204454,0.00001273153,0.006388747,2.164922e-7,0.9497994,0.00002411389,0.00009916084,0.001756495],"study_design_scores_gemma":[0.003973966,0.000153171,0.229491,0.0008040064,0.00003739087,0.000003418104,0.0007349889,0.00003766654,0.7642859,0.0002695712,0.0000253831,0.0001835255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879652,0.01134427,0.000003646528,0.00007948797,0.0000865915,0.0002566096,0.00001006831,0.00006266847,0.0001914996],"genre_scores_gemma":[0.9981245,0.0003830261,0.0001589302,0.00001664548,0.00001914353,0.00003427777,0.0004100456,0.00001248027,0.0008409428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1888818,"threshold_uncertainty_score":0.5154667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02731215793218775,"score_gpt":0.2111121018193191,"score_spread":0.1837999438871314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}