{"id":"W802300164","doi":"10.1371/journal.pone.0132061","title":"Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; Children's Hospital Foundation; National Institutes of Health; Michael Smith Health Research BC; BC Children's Hospital","keywords":"Biology; Gene expression; Gene; Young adult; Transcriptome; Context (archaeology); Innate immune system; Immunology; Immune system; Monocyte; Gene expression profiling; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001859545,0.0001372093,0.0002401609,0.0004296702,0.0002065611,0.0003043935,0.00007785529,0.0002204461,0.001424162],"category_scores_gemma":[0.000466277,0.000131089,0.0001404192,0.0003545712,0.000112965,0.0001258952,0.0002232052,0.0002125839,0.000409257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008620436,"about_ca_system_score_gemma":0.0001070744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007453248,"about_ca_topic_score_gemma":0.001067327,"domain_scores_codex":[0.9998666,0.00001480976,0.00001528918,0.00004583077,0.00002857165,0.00002884755],"domain_scores_gemma":[0.9998369,0.0000311696,0.00004413517,0.00001518132,0.00004001638,0.00003249532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002879371,0.00008313425,0.2761078,0.0003575064,0.00009637233,0.001317953,0.001934644,0.0001658578,0.6742127,0.0002307757,0.0009463536,0.04166758],"study_design_scores_gemma":[0.00001413284,0.0003651575,0.9708812,0.00003968174,0.00005537345,0.001469988,0.0008380177,0.0001830187,0.0228623,0.0001668251,0.003106317,0.00001793102],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995101,0.001814901,0.0007760048,0.00005353983,0.00001865077,0.00001881127,0.001577835,0.000009806467,0.0006294649],"genre_scores_gemma":[0.9919093,0.001911104,0.001789011,0.0002133235,0.00003606675,0.000104212,0.002771413,0.00001220675,0.001253283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424162,"threshold_uncertainty_score":0.004764318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02731215793218775,"score_gpt":0.2111121018193191,"score_spread":0.1837999438871314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}