{"id":"W804767602","doi":"10.1016/j.nicl.2015.06.007","title":"Altered whole-brain white matter networks in preclinical Alzheimer's disease","year":2015,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; Janssen Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; Servier; Innogenetics; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Novartis Pharmaceuticals Corporation; IXICO; Takeda Pharmaceutical Company; Medpace; Genentech; Biogen Idec; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Merck; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Neurodegeneration; White matter; Diffusion MRI; Fractional anisotropy; Neuroscience; Neuroimaging; Connectome; Medicine; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Psychology; Disease; Pathology; Functional connectivity; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008511691,0.0002639604,0.0005658643,0.00009668129,0.00004266683,0.00003972382,0.0002947105,0.0001570087,0.00009235284],"category_scores_gemma":[0.001215599,0.0002444279,0.0002653272,0.0003091933,0.0003370852,0.0001557795,0.0002504153,0.001207856,0.0003742001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002563365,"about_ca_system_score_gemma":0.0001460342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000350964,"about_ca_topic_score_gemma":0.000002169869,"domain_scores_codex":[0.9968661,0.0003082668,0.001122898,0.0009531147,0.0002909819,0.0004586571],"domain_scores_gemma":[0.9968873,0.0006239389,0.0001839331,0.001247656,0.0001104394,0.000946726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005920968,0.0007721877,0.78729,0.000008545027,0.00001193099,0.0003252319,0.00001278833,0.0001244854,0.00001809185,0.00006042097,0.2065208,0.004263471],"study_design_scores_gemma":[0.002649836,0.0003670187,0.8671364,0.00007320449,0.0001198607,0.00005744232,0.000006527966,0.01179989,0.000006114761,0.001115366,0.11642,0.0002484016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4923576,0.001186962,0.04601541,0.4424554,0.00203749,0.00465714,0.0001044023,0.001700366,0.009485177],"genre_scores_gemma":[0.9434824,0.00005540875,0.01063379,0.04262891,0.001224698,0.0001618621,0.0001051723,0.0001191846,0.001588573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4511248,"threshold_uncertainty_score":0.996748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2835831370933138,"score_gpt":0.4784078602423419,"score_spread":0.1948247231490282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}