{"id":"W8054396","doi":"10.1089/scd.2014.0010","title":"Redox Regulation of Canonical Wnt Signaling Affects Extraembryonic Endoderm Formation","year":2014,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Wnt signaling pathway; Biology; Endoderm; Cell biology; Dishevelled; Retinoic acid; Transcription factor; Signal transduction; Reactive oxygen species; Cellular differentiation; Biochemistry; Gene; Frizzled","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009128267,0.0002031509,0.0001561177,0.0001329527,0.000106165,0.0002305916,0.0001241015,0.0002155173,0.0009712184],"category_scores_gemma":[0.00008851504,0.0001323619,0.0001669013,0.0000760731,0.0001935617,0.0001753418,0.0001324291,0.0002630762,0.0001304484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525262,"about_ca_system_score_gemma":0.0001251072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006382104,"about_ca_topic_score_gemma":0.001286533,"domain_scores_codex":[0.9999013,0.00002030028,0.00001019303,0.00002359486,0.00001745846,0.00002715255],"domain_scores_gemma":[0.9999248,0.00001200237,0.00002155833,0.000007011907,0.000007361919,0.00002720728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007354508,0.000006547048,0.0001330493,0.000007338264,0.000001616825,0.00001913039,0.000006264413,0.000008432785,0.9994285,0.00003237606,0.000004672547,0.0002785203],"study_design_scores_gemma":[0.000008606986,0.0001316404,0.009344387,0.000001716232,0.000008976759,0.00007867682,0.00002756624,0.0002056227,0.9895229,0.00002563059,0.0006418553,0.000002473119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980489,0.0008495302,0.0003713518,0.00003657783,0.0000110663,0.000004865003,0.00009854638,0.00001435046,0.0005649585],"genre_scores_gemma":[0.9976255,0.0004581013,0.0003386615,0.00001949652,0.000003573652,0.000006096829,0.00009429307,0.000004178939,0.001450061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009712184,"threshold_uncertainty_score":0.003249109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106575922663227,"score_gpt":0.2170924149877775,"score_spread":0.2064348227214548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}