{"id":"W807657416","doi":"10.71781/11398","title":"Semisynthetic aminoglycoside antibiotics : toward biomimetic synthesis, evasion of bacterial resistance and reduced toxicity","year":2010,"lang":"en","type":"dissertation","venue":"Library and Archives Canada (Government of Canada)","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Achaogen","keywords":"Aminoglycoside; Antibiotics; Toxicity; Microbiology; Antibiotic resistance; Chemistry; Evasion (ethics); Pharmacology; Biology; Immunology; Organic chemistry; Immune system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953451,0.0003941531,0.0002320879,0.0001792593,0.0001167469,0.0003556196,0.0002097829,0.0003755039,0.001292112],"category_scores_gemma":[0.0001832332,0.0001822616,0.0002269217,0.0001409491,0.0002606366,0.0003561959,0.0002630133,0.0003939615,0.0004728182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003228037,"about_ca_system_score_gemma":0.0002851482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003395646,"about_ca_topic_score_gemma":0.0006480477,"domain_scores_codex":[0.9998727,0.00002411182,0.00001115399,0.00002417823,0.0000530966,0.0000147396],"domain_scores_gemma":[0.9998691,0.00001864976,0.00004338035,0.00001649421,0.00003229102,0.00001999488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003409722,0.00000975334,0.00004192262,0.00006616533,0.000002136719,0.00001397625,0.00001040075,0.00005859638,0.996918,0.0001983328,0.00002688959,0.002619735],"study_design_scores_gemma":[0.000009245648,0.0003236762,0.0007132006,0.0000112349,0.000007887345,0.0001555325,0.00001524676,0.0003729253,0.9919784,0.0001006566,0.006306275,0.000005660296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437443,0.0227415,0.0248205,0.0004694572,0.0001382835,0.0001013226,0.0004036751,0.0002315736,0.007349379],"genre_scores_gemma":[0.9528397,0.01050578,0.02234568,0.0001994623,0.00003322765,0.00008987349,0.0005150274,0.00007424784,0.01339693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292112,"threshold_uncertainty_score":0.004322529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004161522830985785,"score_gpt":0.166765702856762,"score_spread":0.1626041800257762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}