{"id":"W807802234","doi":"10.1371/journal.ppat.1005016","title":"Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Japan Society for the Promotion of Science; Burroughs Wellcome Fund; Uehara Memorial Foundation; National Science Foundation","keywords":"Marburg virus; Ebola virus; Virology; Monoclonal antibody; Epitope; Glycoprotein; Immunization; Mucin; Antibody; Biology; Filoviridae; Virus; Ebola vaccine; Ebolavirus; Recombinant DNA; Immunology; Paramyxoviridae; Molecular biology; Viral disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872566,0.0001709579,0.0002393377,0.0001432568,0.0001321419,0.00005633739,0.00004602388,0.0001148438,0.0000962859],"category_scores_gemma":[0.000196995,0.0001304839,0.00003642856,0.0003537936,0.0001208746,0.0001722634,0.00005052631,0.000284328,0.0000453552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001523953,"about_ca_system_score_gemma":0.0001300989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001587025,"about_ca_topic_score_gemma":0.00001121416,"domain_scores_codex":[0.9988787,0.00006652289,0.0001602626,0.0002822622,0.0003442898,0.0002680201],"domain_scores_gemma":[0.9989145,0.00003856342,0.00005504559,0.0002310707,0.0005069587,0.0002538844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001415176,0.0005610161,0.01801242,0.00008061413,0.0002602877,0.00009563203,0.001077514,0.00005521173,0.9753259,0.00005832505,0.0006711436,0.00238678],"study_design_scores_gemma":[0.01566641,0.005918344,0.1557649,0.0003601597,0.0003506519,0.0005645161,0.001567459,0.01216203,0.799383,0.0003837043,0.006873282,0.001005512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915137,0.0002254709,0.003940706,0.0002357154,0.00003725469,0.001117103,0.0001248763,0.0001150626,0.002690152],"genre_scores_gemma":[0.9979218,0.00003237106,0.000422222,0.00006129953,0.00008603331,0.0001729732,0.0001165532,0.00004343111,0.001143292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1759428,"threshold_uncertainty_score":0.532098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02969324366465841,"score_gpt":0.292042487575649,"score_spread":0.2623492439109906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}