{"id":"W807802234","doi":"10.1371/journal.ppat.1005016","title":"Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Japan Society for the Promotion of Science; Burroughs Wellcome Fund; Uehara Memorial Foundation; National Science Foundation","keywords":"Marburg virus; Ebola virus; Virology; Monoclonal antibody; Epitope; Glycoprotein; Immunization; Mucin; Antibody; Biology; Filoviridae; Virus; Ebola vaccine; Ebolavirus; Recombinant DNA; Immunology; Paramyxoviridae; Molecular biology; Viral disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003349466,0.0007149663,0.0002678746,0.0004202316,0.0001441629,0.0002251092,0.0003341349,0.0005729754,0.0008632758],"category_scores_gemma":[0.0002638144,0.000181287,0.0003392017,0.0001388442,0.0001730479,0.0002379268,0.0003460706,0.001081622,0.000235506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003396019,"about_ca_system_score_gemma":0.0001121039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000387194,"about_ca_topic_score_gemma":0.0004690469,"domain_scores_codex":[0.9996222,0.00009193926,0.0000372487,0.00006628967,0.00006567252,0.0001165322],"domain_scores_gemma":[0.9998654,0.00003373601,0.00002888099,0.00002121422,0.00002812838,0.00002261337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001637669,0.0002010714,0.0003897249,0.00004463008,0.00001249113,0.0000557736,0.00002680008,0.0002096502,0.9965363,0.0001048744,0.00005963763,0.002195359],"study_design_scores_gemma":[0.00006926714,0.002432532,0.005016296,0.00001898674,0.00006827967,0.0004564043,0.00002937778,0.00179832,0.9870437,0.00008411416,0.002976695,0.000006066665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937405,0.0009691026,0.003422339,0.00005896184,0.0000612638,0.0001089621,0.0002201423,0.00006655585,0.00135219],"genre_scores_gemma":[0.9944187,0.000803605,0.002991899,0.0001167266,0.00003543836,0.00007325421,0.0006119799,0.0000111649,0.0009371493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008632758,"threshold_uncertainty_score":0.002887964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02969324366465841,"score_gpt":0.292042487575649,"score_spread":0.2623492439109906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}