{"id":"W818293835","doi":"10.1139/y07-107","title":"Senecio latifolius induces in vitro hepatocytotoxicity in a human cell lineThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Senecio; Cytotoxicity; Apoptosis; Glutathione; DNA fragmentation; MTT assay; TUNEL assay; Programmed cell death; Molecular biology; Toxicity; Viability assay; In vitro; Biology; Cell growth; Biochemistry; Chemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148822,0.0007102892,0.0004117558,0.0004408571,0.000220559,0.0002745342,0.0001311109,0.0002467981,0.002562678],"category_scores_gemma":[0.0001591434,0.0001827452,0.0003680713,0.0003342853,0.0001907159,0.000212274,0.00033968,0.0006152059,0.0008673134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693515,"about_ca_system_score_gemma":0.0002002138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137839,"about_ca_topic_score_gemma":0.002010036,"domain_scores_codex":[0.9998623,0.0000290252,0.00002002384,0.00002887914,0.00003450995,0.00002519808],"domain_scores_gemma":[0.9998065,0.00003956088,0.00004748747,0.00004000714,0.00003574137,0.00003083039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002748499,0.00008600279,0.0002908862,0.00007436947,0.00001305621,0.0001977733,0.00003563699,0.00004010065,0.9978841,0.00002007071,0.00005451473,0.001028672],"study_design_scores_gemma":[0.00004523549,0.002312437,0.006263215,0.00001439501,0.00004689218,0.0008364662,0.00008969853,0.0002572386,0.9871094,0.00003055292,0.002988345,0.000006260769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986355,0.006100048,0.002934881,0.0001985943,0.00007164566,0.0001010507,0.0008565853,0.0001089331,0.003273281],"genre_scores_gemma":[0.9885336,0.00308827,0.00145752,0.0001488189,0.00002439219,0.00008748621,0.001749884,0.0000252404,0.004884808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562678,"threshold_uncertainty_score":0.008572996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936207535137888,"score_gpt":0.2665703006530016,"score_spread":0.2472082253016227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}