{"id":"W818293835","doi":"10.1139/y07-107","title":"Senecio latifolius induces in vitro hepatocytotoxicity in a human cell lineThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Senecio; Cytotoxicity; Apoptosis; Glutathione; DNA fragmentation; MTT assay; TUNEL assay; Programmed cell death; Molecular biology; Toxicity; Viability assay; In vitro; Biology; Cell growth; Biochemistry; Chemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009451387,0.0001004619,0.0004106609,0.0001986628,0.00003890818,0.000001602333,0.0001219231,0.000142182,0.0005894665],"category_scores_gemma":[0.00009538129,0.00007719236,0.00003872907,0.0001921515,0.0003586081,0.00001095828,0.0000226945,0.0004112013,9.36587e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003320642,"about_ca_system_score_gemma":0.000304309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001826108,"about_ca_topic_score_gemma":0.004931787,"domain_scores_codex":[0.9985843,0.0003677243,0.0006098416,0.0001532516,0.00005958069,0.0002253449],"domain_scores_gemma":[0.9992273,0.0001393135,0.0003977308,0.00005381797,0.00008924526,0.00009261257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002601593,0.0002020404,0.003300797,0.0001066416,0.00004257981,0.000004331989,0.0008151694,0.0000885807,0.9917291,0.00001290523,0.0006099545,0.0004863383],"study_design_scores_gemma":[0.001422155,0.0007988205,0.04065473,0.00002852658,0.00001213693,0.000006904928,0.00005725212,0.00003045408,0.9561676,0.00004669829,0.000713649,0.00006106574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979181,0.0005821386,2.869843e-7,0.0009487125,0.0001444822,0.0002019046,0.0000329882,4.379301e-7,0.0001709629],"genre_scores_gemma":[0.9986078,0.0003715467,0.00002138037,0.0007184103,0.0002519523,0.000001189178,0.000006581633,0.000003855964,0.00001735324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03735393,"threshold_uncertainty_score":0.6454245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936207535137888,"score_gpt":0.2665703006530016,"score_spread":0.2472082253016227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}