{"id":"W823422456","doi":"10.1056/nejmoa1501646","title":"A Phase 2 Trial of Guselkumab versus Adalimumab for Plaque Psoriasis","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Psoriasis; Placebo; Adalimumab; Internal medicine; Clinical endpoint; Randomization; Gastroenterology; Plaque psoriasis; Surgery; Randomized controlled trial; Dermatology; Tumor necrosis factor alpha; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071791,0.0001627709,0.0006540741,0.0001922094,0.00004151047,0.000002879645,0.0001885091,0.0001574991,0.0001614256],"category_scores_gemma":[0.0008820172,0.0001047804,0.0001523729,0.0001102234,0.0001004445,0.00007152436,0.00001384586,0.0001470433,0.000008600085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004765503,"about_ca_system_score_gemma":0.0003345462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006813944,"about_ca_topic_score_gemma":0.00002729748,"domain_scores_codex":[0.9987429,0.0001859731,0.0006393995,0.0001165787,0.0001107643,0.0002043499],"domain_scores_gemma":[0.998239,0.0006796461,0.0005310666,0.0001620762,0.0002782284,0.0001100268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5701997,0.000699604,0.00002964848,0.00001526807,0.001138897,0.00003222666,0.001917347,0.000006163659,0.01189296,0.0002400937,0.04583748,0.3679907],"study_design_scores_gemma":[0.7795992,0.02773169,0.000009601558,0.00007335061,0.0008513324,0.0001766619,0.0003577753,0.000001314117,0.01189705,0.000367569,0.1788536,0.00008085017],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976597,0.007449416,0.0008762436,0.002213783,0.01161633,0.0003809105,0.00004287697,0.00001420603,0.000809254],"genre_scores_gemma":[0.9946369,0.000389697,0.0004166843,0.00004601846,0.003710667,0.000006391284,0.00005121215,0.00001597238,0.0007264933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3679098,"threshold_uncertainty_score":0.4272819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07114551676151244,"score_gpt":0.3284398490840408,"score_spread":0.2572943323225284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}