{"id":"W835283934","doi":"10.1371/journal.pntd.0003868","title":"PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection","year":2015,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Secretion; Leishmania mexicana; AIM2; Cell biology; Leishmania; Hemozoin; Reactive oxygen species; Biology; Caspase 1; Proinflammatory cytokine; Leishmania major; NADPH oxidase; Chemistry; Microbiology; Inflammation; Immunology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002726322,0.0004139557,0.0006268088,0.0002232694,0.0002021317,0.0003679872,0.0002765589,0.0005107204,0.001426939],"category_scores_gemma":[0.0002926448,0.0002237037,0.000481253,0.0002062759,0.0003366754,0.0004138255,0.0002682257,0.0009420736,0.0005591409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001791805,"about_ca_system_score_gemma":0.0002480626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002021094,"about_ca_topic_score_gemma":0.0002140155,"domain_scores_codex":[0.9997339,0.00005642261,0.00003239333,0.00004347159,0.0000455814,0.00008829067],"domain_scores_gemma":[0.9998174,0.00001281014,0.00007081015,0.00002726004,0.00002009407,0.00005152668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008695695,0.00009423374,0.0001520079,0.000103755,0.000007706218,0.0001166241,0.00002924954,0.00003086641,0.9978483,0.00004500799,0.00004243342,0.000660171],"study_design_scores_gemma":[0.0002347682,0.001955773,0.01641288,0.0000346329,0.0000553104,0.0009469301,0.0001419147,0.001323626,0.9751558,0.0001602057,0.003560296,0.00001779652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940634,0.002608397,0.001942216,0.0002106022,0.00006316313,0.00006162768,0.0002940891,0.00008819174,0.000668184],"genre_scores_gemma":[0.9957837,0.00110866,0.001090386,0.00007478772,0.00003373155,0.000104694,0.0003841275,0.00001612823,0.001403928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426939,"threshold_uncertainty_score":0.004773557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009872895108553242,"score_gpt":0.2165900443136664,"score_spread":0.2067171492051132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}