{"id":"W836150979","doi":"10.1038/sc.2015.95","title":"Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial","year":2015,"lang":"en","type":"article","venue":"Spinal Cord","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Medical Research and Materiel Command; U.S. Army; Rick Hansen Institute; Ontario Neurotrauma Foundation; AOSpine; Telemedicine and Advanced Technology Research Center; Christopher and Dana Reeve Foundation","keywords":"Riluzole; Medicine; Placebo; Randomized controlled trial; Spinal cord injury; Clinical endpoint; Anesthesia; Amyotrophic lateral sclerosis; Internal medicine; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05510525,0.007550735,0.008106281,0.001604433,0.003097895,0.004250829,0.003484719,0.007194606,0.02561831],"category_scores_gemma":[0.04104854,0.003037614,0.004536125,0.002081561,0.005070613,0.004063241,0.00160512,0.007395765,0.008188975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002494057,"about_ca_system_score_gemma":0.01307473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855449,"about_ca_topic_score_gemma":0.001246088,"domain_scores_codex":[0.9589329,0.02714477,0.003433391,0.003980035,0.004440376,0.002068433],"domain_scores_gemma":[0.987532,0.002913862,0.00291131,0.001694815,0.002873262,0.002074811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9033298,0.008837937,0.002108422,0.017988,0.003136041,0.0002202083,0.0004333105,0.001306101,0.002823643,0.008764803,0.01662473,0.03442701],"study_design_scores_gemma":[0.922012,0.03109249,0.002206808,0.002389316,0.002107532,0.00008729989,0.00008581924,0.001631004,0.001075076,0.005736507,0.0314651,0.0001110249],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006774242,0.002727594,0.006251795,0.001549865,0.001901927,0.9752095,0.002549511,0.0001964806,0.002839027],"genre_scores_gemma":[0.01386315,0.000547426,0.008811772,0.001184198,0.0003823903,0.9739313,0.000531639,0.0000204306,0.000727671],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05510525,"threshold_uncertainty_score":0.2914279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2071008537191851,"score_gpt":0.4479689660033035,"score_spread":0.2408681122841184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}