{"id":"W836150979","doi":"10.1038/sc.2015.95","title":"Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial","year":2015,"lang":"en","type":"article","venue":"Spinal Cord","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Medical Research and Materiel Command; U.S. Army; Rick Hansen Institute; Ontario Neurotrauma Foundation; AOSpine; Telemedicine and Advanced Technology Research Center; Christopher and Dana Reeve Foundation","keywords":"Riluzole; Medicine; Placebo; Randomized controlled trial; Spinal cord injury; Clinical endpoint; Anesthesia; Amyotrophic lateral sclerosis; Internal medicine; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004811225,0.0003618861,0.001304728,0.0002373162,0.0002048582,0.0001563704,0.0002916826,0.0001601684,0.00007147976],"category_scores_gemma":[0.001794843,0.0002176126,0.0002714188,0.0002445672,0.0004629402,0.0002260213,0.0001849697,0.0005913214,0.00003748754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824064,"about_ca_system_score_gemma":0.000487664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000169085,"about_ca_topic_score_gemma":0.00006029128,"domain_scores_codex":[0.9959543,0.0008650896,0.0009365684,0.0006024186,0.0009749571,0.0006667002],"domain_scores_gemma":[0.9975668,0.001006967,0.0001518323,0.0003946661,0.0004649386,0.0004147723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9921628,0.001754076,0.0002622447,0.00002953569,0.0004039654,0.00008621033,0.0001013078,0.000007894014,0.00009660049,0.0002766032,0.0008959801,0.003922735],"study_design_scores_gemma":[0.9537455,0.0340537,0.002017071,0.0001041161,0.0004568163,0.00005449697,0.0002411985,0.008320678,0.00001856751,0.0005118957,0.0002453571,0.0002305941],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9022326,0.0007018747,0.04832352,0.009753843,0.0006708807,0.03815676,0.00001931377,0.00005488484,0.00008625124],"genre_scores_gemma":[0.9839846,0.00007500451,0.008873371,0.0004441017,0.0005057129,0.00553065,0.00001276608,0.00004229914,0.0005314419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08175198,"threshold_uncertainty_score":0.8873982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2071008537191851,"score_gpt":0.4479689660033035,"score_spread":0.2408681122841184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}