{"id":"W840952913","doi":"","title":"Preclinical Development of EBI-005: a Potent Interleukin-1 (IL-1) Receptor-1 (R1) Blocker for Topical Ocular Administration was Safe in GLP Toxicology Studies and Active in a Mouse Model of Dry Eye Disease (DED)","year":2013,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001115176,0.001366756,0.0007556637,0.0008153151,0.0004875335,0.0007531584,0.0009023241,0.001107215,0.006200179],"category_scores_gemma":[0.0003831577,0.0004720872,0.0007781179,0.0002871961,0.000694737,0.0009482155,0.0002241288,0.003374848,0.001856864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006652974,"about_ca_system_score_gemma":0.001666969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043289,"about_ca_topic_score_gemma":0.002654409,"domain_scores_codex":[0.9996722,0.00005438332,0.00001995464,0.00006444353,0.00006246267,0.0001267212],"domain_scores_gemma":[0.9996288,0.0000404671,0.0000667114,0.00003482662,0.00006530901,0.0001638829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01021374,0.01051361,0.0005170897,0.0005527079,0.000131795,0.0002809586,0.0002135766,0.001434102,0.9369045,0.001306191,0.003467517,0.03446421],"study_design_scores_gemma":[0.006761935,0.0980746,0.002778649,0.0001014916,0.0003936177,0.0005031437,0.0001174597,0.001592422,0.8600768,0.0003415491,0.02922026,0.0000381298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475251,0.006314219,0.01944142,0.001278604,0.0005880256,0.00357384,0.00605532,0.00105596,0.01416752],"genre_scores_gemma":[0.9513767,0.006298364,0.0138871,0.0006315563,0.0001778104,0.002352583,0.007517895,0.0001403632,0.01761755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006200179,"threshold_uncertainty_score":0.02074164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07694664944630021,"score_gpt":0.3895111160423737,"score_spread":0.3125644665960735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}