{"id":"W84335606","doi":"10.1161/circ.118.suppl_18.s_406","title":"Abstract 1924: Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic Beta Cell Dysfunction","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"","keywords":"Internal medicine; Endocrinology; ABCA1; Medicine; Insulin; Glucose homeostasis; Homeostasis; Cholesterol; Beta cell; Insulin resistance; Transporter; Biology; Biochemistry; Islet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671954,0.0005568704,0.0003968498,0.0003660964,0.0001870563,0.0003003683,0.0002558966,0.0004970062,0.01226004],"category_scores_gemma":[0.0003364311,0.0001619212,0.0002320706,0.0002036065,0.0003483254,0.000211049,0.0002674497,0.0005166393,0.001864566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001210225,"about_ca_system_score_gemma":0.00009777552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005318612,"about_ca_topic_score_gemma":0.0002303799,"domain_scores_codex":[0.9998711,0.00002069779,0.00001954118,0.00003752921,0.00002866859,0.00002230843],"domain_scores_gemma":[0.9998069,0.00004253618,0.00005959919,0.00001825363,0.00001643573,0.00005623216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004489591,0.0003538414,0.01527301,0.00010059,0.00008726091,0.005321499,0.000121062,0.00005326496,0.9650231,0.0001873002,0.001164168,0.007825259],"study_design_scores_gemma":[0.001114837,0.007842166,0.5168888,0.00008043518,0.0005918045,0.1000737,0.0006236278,0.001721646,0.3484081,0.0009508145,0.02159736,0.0001066958],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971322,0.0003959939,0.0007229164,0.0001543843,0.00008109772,0.00001635162,0.000628291,0.00005609317,0.000812669],"genre_scores_gemma":[0.9931512,0.0002884464,0.0005659953,0.0001348955,0.00006112514,0.00004747518,0.0009838986,0.00006827422,0.00469882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226004,"threshold_uncertainty_score":0.04101396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930385121099681,"score_gpt":0.2493455252812314,"score_spread":0.2300416740702345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}