{"id":"W851077011","doi":"10.1097/jto.0000000000000548","title":"Multitrial Evaluation of Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Extensive-Stage Small-Cell Lung Cancer","year":2015,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Surrogate endpoint; Medicine; Hazard ratio; Progression-free survival; Internal medicine; Confidence interval; Proportional hazards model; Oncology; Lung cancer; Clinical endpoint; Randomized controlled trial; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0244146,0.001402087,0.002632492,0.0004150409,0.0005621974,0.00189484,0.0008922886,0.00189774,0.002682117],"category_scores_gemma":[0.01350192,0.0005822118,0.003217259,0.0006706538,0.001291935,0.001708887,0.0009406906,0.004614396,0.0005406147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001136211,"about_ca_system_score_gemma":0.001948324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005196735,"about_ca_topic_score_gemma":0.001785366,"domain_scores_codex":[0.9884022,0.009608014,0.0006083926,0.0004677944,0.0004545257,0.0004591263],"domain_scores_gemma":[0.9898468,0.00404782,0.002473857,0.001358155,0.00112704,0.001146346],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9630519,0.00356591,0.005866057,0.0008838189,0.003752603,0.00003276637,0.0001721151,0.0008811014,0.002772275,0.0004409506,0.0006396845,0.01794075],"study_design_scores_gemma":[0.582077,0.3805434,0.02334334,0.0003517036,0.004654109,0.0001351842,0.000244788,0.00185107,0.002153277,0.0009095885,0.003669284,0.00006725526],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787146,0.009873953,0.00217125,0.0009931959,0.0006426041,0.003257574,0.001164547,0.00005926225,0.003122943],"genre_scores_gemma":[0.9926175,0.001300263,0.001387086,0.000343723,0.0002114811,0.002587311,0.0006925764,0.00002522558,0.0008347851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9755854,"threshold_uncertainty_score":0.1291183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1375527453718126,"score_gpt":0.5236198700037795,"score_spread":0.386067124631967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}