{"id":"W85244076","doi":"10.4049/jimmunol.190.supp.120.7","title":"Glucocorticoid induces pentraxin 3 expression through mitogen-activated protein kinase pathway in human airway smooth muscle cells (P6013)","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Saint-Boniface; St. Boniface Hospital; University of Manitoba","funders":"","keywords":"PTX3; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Inflammation; Innate immune system; Tumor necrosis factor alpha; Transfection; Messenger RNA; Protein kinase A; Cell biology; Chemistry; Kinase; Receptor; Biology; Medicine; Internal medicine; Endocrinology; Immunology; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006180885,0.0003259484,0.0005587463,0.0002205132,0.0002289719,0.00002814259,0.0009811255,0.000502624,0.002384694],"category_scores_gemma":[0.0001141506,0.0002173051,0.0001728932,0.0002630162,0.0004516984,0.0004102575,0.0002696812,0.001100723,0.0004076241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316221,"about_ca_system_score_gemma":0.0001574167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003265621,"about_ca_topic_score_gemma":0.00001003631,"domain_scores_codex":[0.9966189,0.001449374,0.0009408207,0.0002507079,0.0001014424,0.000638814],"domain_scores_gemma":[0.9980744,0.0002068793,0.0008899842,0.0005884304,0.0002058236,0.00003451871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005289888,0.0003838577,0.0000370153,0.00001762948,0.0001673838,0.00002303601,0.00140144,0.000005511968,0.9924789,0.0001221047,0.0009062584,0.00392789],"study_design_scores_gemma":[0.002853207,0.0007333331,0.004781045,0.0001989232,0.00003163001,0.00006349976,0.001819528,6.915227e-7,0.9844524,0.001399721,0.003429921,0.0002361223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907871,0.005857837,0.0001283198,0.0004459689,0.001612035,0.0008656505,0.000008978134,0.00003173128,0.0002623544],"genre_scores_gemma":[0.9988495,0.0001378731,0.0001763549,0.0001478507,0.00004465667,0.00004387087,0.00001147656,0.00003914975,0.0005493406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008062303,"threshold_uncertainty_score":0.9985273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129597237286319,"score_gpt":0.2282955908949025,"score_spread":0.2153358671662705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}