{"id":"W853742876","doi":"","title":"Topical small molecule translational bypass therapy rescues Pax6 aniridia mutant phenotype","year":2013,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"PAX6; Aniridia; Phenotype; Mutant; Small molecule; Medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001495177,0.0005933077,0.0004182204,0.0004248864,0.000319908,0.0003720188,0.0004645913,0.0008209809,0.005044258],"category_scores_gemma":[0.0001410892,0.0002255785,0.0004206105,0.0001517217,0.0004526518,0.0002733243,0.0002929162,0.001565304,0.00100155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609536,"about_ca_system_score_gemma":0.0003545871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008883854,"about_ca_topic_score_gemma":0.001308664,"domain_scores_codex":[0.9998024,0.0000198178,0.00002063165,0.00004902319,0.0000731164,0.00003511909],"domain_scores_gemma":[0.9998202,0.0000443412,0.00004321822,0.00002413825,0.0000111589,0.00005694244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005291129,0.00003395879,0.00003099503,0.00001671579,0.000003744,0.0001477361,0.000006276684,0.00003436063,0.9985606,0.0001321966,0.00008399296,0.0008965822],"study_design_scores_gemma":[0.00004037119,0.0001815296,0.001152984,0.000006230071,0.00001819007,0.0007754979,0.0000324473,0.001006737,0.994105,0.0001068872,0.002565393,0.000008680395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981221,0.001373225,0.009012792,0.0006468391,0.0003661654,0.0001092252,0.0009694495,0.0009016067,0.00539976],"genre_scores_gemma":[0.9838012,0.0008055324,0.003982852,0.0001199125,0.00003330669,0.00006404572,0.0003672646,0.0001293875,0.01069664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005044258,"threshold_uncertainty_score":0.01687473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810937773255325,"score_gpt":0.334303731089122,"score_spread":0.3061943533565688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}