{"id":"W866387138","doi":"10.1158/1538-7445.panca2014-a102","title":"Abstract A102: Combination treatment with hypoxia-activated prodrug TH-302 and radiation reduce pancreatic tumor initiating cells and tumor growth in patient-derived xenografts","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pancreatic cancer; Tumor hypoxia; Medicine; Hypoxia (environmental); Radiation therapy; Prodrug; Metastasis; Immunostaining; Cancer research; Combination therapy; Pancreatic tumor; Primary tumor; Tumor progression; Cancer; Internal medicine; Pharmacology; Chemistry; Immunohistochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796223,0.0003599492,0.0003547988,0.0001976739,0.00008510667,0.0002001899,0.0002035863,0.0002304647,0.002207587],"category_scores_gemma":[0.0001162846,0.0001119394,0.0002183765,0.0001396161,0.0001615948,0.0001163301,0.0001170917,0.0005027453,0.0003605978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737995,"about_ca_system_score_gemma":0.0002480118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734748,"about_ca_topic_score_gemma":0.0006813419,"domain_scores_codex":[0.9998868,0.00002343224,0.00001159225,0.0000224291,0.00002874112,0.00002708445],"domain_scores_gemma":[0.9998978,0.00002368103,0.00001897439,0.00001459969,0.000007651152,0.00003732548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002070782,0.0005652379,0.0006887728,0.00006951013,0.00002381446,0.00007995174,0.0000182016,0.0003406772,0.9916188,0.00006681059,0.000251705,0.004205722],"study_design_scores_gemma":[0.0003059458,0.009184407,0.004721208,0.000005874223,0.00004178405,0.0005220625,0.00001818642,0.001306597,0.9821047,0.00002037921,0.001763645,0.000005319114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996986,0.0005557077,0.0007440177,0.00004404068,0.00002264077,0.00007607298,0.0002803945,0.00004902768,0.001242219],"genre_scores_gemma":[0.9961539,0.0002565714,0.001298689,0.00002612856,0.00001173278,0.00005089301,0.0006188753,0.00001135655,0.001571825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002207587,"threshold_uncertainty_score":0.007385075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0444329143173956,"score_gpt":0.3374101986801193,"score_spread":0.2929772843627237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}