{"id":"W873049904","doi":"10.1016/j.ydbio.2015.07.010","title":"The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans","year":2015,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Cell biology; Rho-associated protein kinase; GTPase; Elongation; Morphogenesis; Caenorhabditis elegans; Myosin; Guanine nucleotide exchange factor; Myosin light-chain kinase; Phosphatase; Kinase; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357695,0.0004897967,0.0002120756,0.000366754,0.0004024044,0.0003991764,0.0002947055,0.0003723873,0.0009256777],"category_scores_gemma":[0.000182441,0.0002666576,0.0002541906,0.00008354661,0.0003205237,0.0002663742,0.000400408,0.0005882669,0.0006249683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004264997,"about_ca_system_score_gemma":0.0003764121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002176834,"about_ca_topic_score_gemma":0.005065852,"domain_scores_codex":[0.9998642,0.00001625091,0.000006938439,0.00002589902,0.00005253249,0.00003409801],"domain_scores_gemma":[0.999922,0.00001083875,0.00001683419,0.00001318726,0.00001352104,0.00002368689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007385513,0.000007852363,0.0001974416,0.00002157573,0.000003664379,0.0001411415,0.00001011476,0.0001542418,0.9967684,0.0005591537,0.0001413298,0.001921256],"study_design_scores_gemma":[0.00001646456,0.0000765488,0.004833345,0.00001218289,0.00001200767,0.0003823387,0.00002367582,0.0022364,0.9864559,0.0002128998,0.005725334,0.00001287692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737045,0.003045102,0.0100516,0.0003004889,0.0001088404,0.00003274609,0.0004359154,0.0006459802,0.0116749],"genre_scores_gemma":[0.9880188,0.0008789568,0.00372585,0.00005943852,0.00001417972,0.00001850482,0.0003853922,0.00007719421,0.006821722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176834,"threshold_uncertainty_score":0.00432831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236355586400432,"score_gpt":0.2753698597675827,"score_spread":0.2430063039035784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}