{"id":"W874793669","doi":"10.1021/acs.chemrev.5b00154","title":"A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad Actors","year":2015,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Novartis; Alfred P. Sloan Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Natural Sciences and Engineering Research Council of Canada; Amgen; Boehringer Ingelheim","keywords":"Chemistry; Alkaloid; Group (periodic table); Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002069316,0.0001913734,0.0002158988,0.0007774667,0.0007672116,0.001172145,0.0002895802,0.000512763,0.007139658],"category_scores_gemma":[0.00506497,0.0002123159,0.0003458645,0.0007855401,0.0002822159,0.00105095,0.0008913722,0.001426523,0.001496507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005098952,"about_ca_system_score_gemma":0.0004452294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004494026,"about_ca_topic_score_gemma":0.005801525,"domain_scores_codex":[0.9995022,0.0001518839,0.00002606728,0.0001267735,0.00009712435,0.00009594413],"domain_scores_gemma":[0.9962544,0.0004701896,0.001159842,0.0006635361,0.0007280259,0.0007239721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001629567,0.0008075057,0.9070131,0.00007868595,0.0002675112,0.0003321771,0.001800417,0.0001497818,0.005468739,0.002267638,0.01145293,0.06873185],"study_design_scores_gemma":[0.00001554471,0.0005025259,0.9887022,0.00004384038,0.00008700851,0.0001958777,0.0007725089,0.0003141711,0.0009506264,0.001607949,0.006785277,0.0000226024],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9842587,0.002149379,0.001520311,0.001752731,0.00009169487,0.00004504253,0.004516775,0.00006795611,0.005597519],"genre_scores_gemma":[0.9884534,0.0008017769,0.0006830736,0.0003181474,0.00004965564,0.00004903106,0.002938383,0.00003839133,0.006668202],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007139658,"threshold_uncertainty_score":0.02388453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1380528931890393,"score_gpt":0.3540880162204005,"score_spread":0.2160351230313612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}