{"id":"W886495568","doi":"10.1021/jacs.5b05076","title":"Unsymmetrical Diarylmethanes by Ferroceniumboronic Acid Catalyzed Direct Friedel–Crafts Reactions with Deactivated Benzylic Alcohols: Enhanced Reactivity due to Ion-Pairing Effects","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Reactions","field":"Chemistry","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; American Chemical Society Petroleum Research Fund; Alberta Ingenuity; Alberta Innovates - Health Solutions","keywords":"Chemistry; Catalysis; Carbocation; Boronic acid; Friedel–Crafts reaction; Regioselectivity; Nucleophile; Acid catalysis; SN2 reaction; Organic chemistry; Lewis acids and bases; Salt (chemistry); Reactivity (psychology); Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725204,0.0005318558,0.0002668786,0.0001797158,0.0001055867,0.0001598392,0.000281331,0.0002724786,0.001009416],"category_scores_gemma":[0.0001393112,0.0001708267,0.0001725548,0.0001694636,0.0001938147,0.0003304594,0.0002729355,0.000499317,0.0005528782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672009,"about_ca_system_score_gemma":0.0001898513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003854943,"about_ca_topic_score_gemma":0.001218658,"domain_scores_codex":[0.9999013,0.0000131363,0.000008102509,0.00002242008,0.00002008702,0.00003491278],"domain_scores_gemma":[0.9999335,0.00001107061,0.00002388765,0.00001055968,0.000009908066,0.00001111311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007258452,0.00002459507,0.00009370247,0.00009592046,0.000006626121,0.00007009149,0.00004788594,0.0001263001,0.9948928,0.0003774849,0.00005745151,0.004134505],"study_design_scores_gemma":[0.000008596589,0.00009265857,0.0002939467,0.000003683642,0.000005702964,0.00009360963,0.000005634384,0.000326616,0.997898,0.00002837425,0.001239802,0.000003447043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836827,0.001738488,0.009887454,0.0001089728,0.00002544294,0.00005160499,0.0001624265,0.0001130703,0.004229832],"genre_scores_gemma":[0.9902075,0.001313421,0.005720241,0.00003495394,0.00001100007,0.0000273256,0.00020682,0.00002920464,0.002449646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009416,"threshold_uncertainty_score":0.003376782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163371131112216,"score_gpt":0.2479699557400838,"score_spread":0.2363362444289616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}