{"id":"W886495568","doi":"10.1021/jacs.5b05076","title":"Unsymmetrical Diarylmethanes by Ferroceniumboronic Acid Catalyzed Direct Friedel–Crafts Reactions with Deactivated Benzylic Alcohols: Enhanced Reactivity due to Ion-Pairing Effects","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Chemical Synthesis and Reactions","field":"Chemistry","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; American Chemical Society Petroleum Research Fund; Alberta Ingenuity; Alberta Innovates - Health Solutions","keywords":"Chemistry; Catalysis; Carbocation; Boronic acid; Friedel–Crafts reaction; Regioselectivity; Nucleophile; Acid catalysis; SN2 reaction; Organic chemistry; Lewis acids and bases; Salt (chemistry); Reactivity (psychology); Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004529342,0.0004272654,0.0009889589,0.00005060527,0.000209497,0.00007184811,0.0006908154,0.0002092761,0.00002549136],"category_scores_gemma":[0.002172356,0.0002739058,0.0007787451,0.00137036,0.0003679588,0.0002604366,0.0002191158,0.001301887,0.000009241865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001327834,"about_ca_system_score_gemma":0.0002615317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005089064,"about_ca_topic_score_gemma":0.000009114511,"domain_scores_codex":[0.9972361,0.00009990283,0.000639002,0.0004735851,0.000935448,0.000616],"domain_scores_gemma":[0.9956907,0.001310694,0.001341763,0.0005634638,0.0003300457,0.0007633438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003352491,0.0005324638,0.00036123,0.00004070097,0.000430626,0.000007414705,0.0002527851,0.00002059382,0.9864729,0.00000110644,0.005235361,0.006309537],"study_design_scores_gemma":[0.0009048664,0.00007200156,0.0003459509,0.0001987539,0.0002557438,0.0001567518,0.0006194236,0.00003543533,0.9912405,0.00003892596,0.005741874,0.0003897447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951892,0.0002337497,0.0006478262,0.001979278,0.000137854,0.0001376533,0.00002423096,0.00009124983,0.001558888],"genre_scores_gemma":[0.9977099,0.00007189806,0.001277409,0.0002644522,0.0004406055,0.0000324045,0.00001000731,0.00006816072,0.0001251383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005919793,"threshold_uncertainty_score":0.9999713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163371131112216,"score_gpt":0.2479699557400838,"score_spread":0.2363362444289616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}