{"id":"W88971926","doi":"10.3233/jhd-2012-129000","title":"Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons","year":2012,"lang":"en","type":"article","venue":"Journal of Huntington s Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute on Aging; Canadian Institutes of Health Research; Fondation pour la Recherche sur Alzheimer","keywords":"Excitotoxicity; Neurodegeneration; Quinolinic acid; Huntingtin; Medium spiny neuron; Striatum; Cyclin-dependent kinase 5; Huntington's disease; Biology; NMDA receptor; Neuroprotection; Glutamate receptor; Neuroscience; Cell biology; Apoptosis; Programmed cell death; Protein kinase A; Internal medicine; Kinase; Receptor; Medicine; Cyclin-dependent kinase 2; Biochemistry; Dopamine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003395944,0.0001675593,0.0002447705,0.0001515714,0.0001259253,0.00005484249,0.0003400422,0.00002965174,0.00003558833],"category_scores_gemma":[0.004176226,0.0001205886,0.0001538153,0.0003165238,0.0002154974,0.0005092765,0.0001700391,0.0002468737,9.317313e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002948358,"about_ca_system_score_gemma":0.0002266961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005471645,"about_ca_topic_score_gemma":0.000001240192,"domain_scores_codex":[0.9979333,0.000534999,0.0005052279,0.0001964945,0.0005131911,0.0003168385],"domain_scores_gemma":[0.9983124,0.0003590313,0.0006310008,0.0002263121,0.00007042083,0.0004008902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001420239,0.0003517258,0.246992,0.00002537353,0.000004891155,0.000003205975,0.0001939514,0.00004753652,0.7512763,0.0001167673,0.00005197491,0.0007942684],"study_design_scores_gemma":[0.0002968688,0.00002185802,0.4791034,0.00005503043,0.00002147794,0.000004447364,0.00005932372,0.00001039905,0.5202305,0.00009638532,0.0000369404,0.00006334666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988088,0.0001599642,0.00001142533,0.0002956013,0.0004338773,0.0001672229,0.00005309369,0.000006128483,0.00006389927],"genre_scores_gemma":[0.9994065,0.00002823737,0.00008341666,0.0002366632,0.0002078741,0.000001986416,1.590296e-7,0.00001910399,0.00001609547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2321115,"threshold_uncertainty_score":0.4999633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427897526186172,"score_gpt":0.290286029073555,"score_spread":0.2474962764549378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}