{"id":"W895230571","doi":"10.1016/j.ijpharm.2015.07.021","title":"Lipid-based nanoparticles containing cationic derivatives of PTA (1,3,5-triaza-7-phosphaadamantane) as innovative vehicle for Pt complexes: Production, characterization and in vitro studies","year":2015,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Petroleum Technology Alliance Canada","keywords":"Phosphine; Cationic polymerization; Chemistry; Nanoparticle; Dithiocarbamate; Ligand (biochemistry); Platinum; Alkylation; Combinatorial chemistry; Yield (engineering); Metal; In vitro; Stereochemistry; Nuclear chemistry; Organic chemistry; Nanotechnology; Materials science; Biochemistry; Catalysis; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978683,0.0002517737,0.0001871221,0.0001424986,0.0001287202,0.0002260148,0.000217317,0.0003367978,0.000512466],"category_scores_gemma":[0.0001804652,0.0001555418,0.0001614754,0.0001035722,0.0002011052,0.0002765747,0.0001703923,0.0003304049,0.0002450945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002503452,"about_ca_system_score_gemma":0.000152398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005406154,"about_ca_topic_score_gemma":0.0005861598,"domain_scores_codex":[0.9999033,0.00001448628,0.000007418134,0.00003030583,0.0000255216,0.00001893819],"domain_scores_gemma":[0.9999253,0.00002041477,0.00002068993,0.0000059084,0.00001503995,0.00001263466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000556406,0.00001071017,0.00002220668,0.00002764861,0.000003104985,0.00003200353,0.00001219935,0.00005777338,0.9991109,0.0000633485,0.00001621209,0.0005883033],"study_design_scores_gemma":[0.000007487349,0.000125333,0.0001398492,0.000001857903,0.000008624925,0.00008217871,0.00000560305,0.0003857287,0.998601,0.00001489375,0.0006256398,0.000001891186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858503,0.001901062,0.01027306,0.0001095882,0.00004925986,0.00005550095,0.0001124432,0.0001022773,0.001546587],"genre_scores_gemma":[0.9931868,0.0006918965,0.004000165,0.00003566301,0.000008426866,0.00003176459,0.0001204891,0.00001865349,0.001906119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005406154,"threshold_uncertainty_score":0.001816332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0947520671199736,"score_gpt":0.3790171588661813,"score_spread":0.2842650917462077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}